MEGESTROL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does megestrol mean? 

• MEGESTROL (noun)
  The noun MEGESTROL has 1 sense:

1. a synthetic progestational compound used to treat endometrial carcinoma

  Familiarity information: MEGESTROL used as a noun is very rare.

 Dictionary entry details 

• MEGESTROL (noun)

Sense 1

Meaning:

A synthetic progestational compound used to treat endometrial carcinoma

Classified under:

Nouns denoting substances

Synonyms:

megestrol; megestrol acetate

Hypernyms ("megestrol" is a kind of...):

progestin; progestogen (any of a group of steroid hormones that have the effect of progesterone)

 Context examples 

Megestrol acetate is a type of progestin.

(Megestrol acetate, NCI Dictionary)

Megestrol belongs to the group of hormones called progestins.

(Megestrol, NCI Dictionary)

Megestrol binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription.

(Megestrol, NCI Thesaurus)

Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.

(Megestrol acetate, NCI Thesaurus)

Also called megestrol acetate.

(Megace, NCI Dictionary)

In addition, megestrol stimulates appetite in cachectic subjects.

(Megestrol, NCI Thesaurus)

Megestrol acetate blocks the effects of the hormone estrogen in the body, which may help keep some cancer cells from growing.

(Megestrol acetate, NCI Dictionary)

Mimicking the action of progesterone, megestrol acetate binds to and activates nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes.

(Megestrol acetate, NCI Thesaurus)