MEDIATOR

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does mediator mean? 

• MEDIATOR (noun)
  The noun MEDIATOR has 1 sense:

1. a negotiator who acts as a link between parties

  Familiarity information: MEDIATOR used as a noun is very rare.

 Dictionary entry details 

• MEDIATOR (noun)

Sense 1

Meaning:

A negotiator who acts as a link between parties

Classified under:

Nouns denoting people

Synonyms:

go-between; intercessor; intermediary; intermediator; mediator

Hypernyms ("mediator" is a kind of...):

negotiant; negotiator; treater (someone who negotiates (confers with others in order to reach a settlement))

Hyponyms (each of the following is a kind of "mediator"):

mediatrix (a woman who is a mediator)

conciliator; make-peace; pacifier; peacemaker; reconciler (someone who tries to bring peace)

diplomat (a person who deals tactfully with others)

harmoniser; harmonizer (a mediator who brings one thing into harmonious agreement with another)

interpreter; translator (someone who mediates between speakers of different languages)

marriage broker; matcher; matchmaker (someone who arranges (or tries to arrange) marriages for others)

moderator (someone who mediates disputes and attempts to avoid violence)

second hand (an intermediate person; used in the phrase 'at second hand')

Derivation:

mediate (act between parties with a view to reconciling differences)

 Context examples 

This agent also inhibits vascular endothelial growth factor receptor 1 (VEGFR1) and vascular endothelial growth factor receptor 3 (VEGFR3), important mediators of tumor angiogenesis and lymphogenesis, respectively.

(Checkpoint Kinase Inhibitor XL844, NCI Thesaurus)

Possible upstream mediators of cinobufagin-induced apoptosis include Fas and p53.

(Cinobufagin, NCI Thesaurus)

The JAK-STAT signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types.

(Momelotinib, NCI Thesaurus)

This gene is a mediator of cell-cell adhesion and a negative regulator of neural growth.

(CDH13 Gene, NCI Thesaurus)

This gene is a mediator in cell cycle regulation.

(CCNB2 Gene, NCI Thesaurus)

Mice lacking the c-Fos gene have overly dense bone and decreased bone resorption due to reduced osteoclast differentiation, indicating that c-Fos is an important mediator of osteoclast differentiation.

(Bone Remodeling Pathway, NCI Thesaurus/BIOCARTA)

MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in various cancer cells.

(Carbon C 14 Selumetinib, NCI Thesaurus)

Montelukast selectively and competitively blocks the cysteinyl leukotriene 1 (CysLT1) receptor, preventing binding of the inflammatory mediator leukotriene D4 (LTD4).

(Montelukast sodium, NCI Thesaurus)

Inflammation is induced by release of vasodilatory, opsonizing, and chemotactic mediators that attract phagocytizing macrophages and leukocytes; dilate local blood vessels, increasing local blood flow and capillary permeability; and induce pain.

(Negative Regulation of Inflammatory Response Process, NCI Thesaurus)

Pemirolast potassium also prevents inflammatory mediator release from eosinophils.

(Pemirolast Potassium, NCI Thesaurus)