MAST CELL

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 Dictionary entry overview: What does mast cell mean? 

• MAST CELL (noun)
  The noun MAST CELL has 1 sense:

1. a large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation

  Familiarity information: MAST CELL used as a noun is very rare.

 Dictionary entry details 

• MAST CELL (noun)

Sense 1

Meaning:

A large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation

Classified under:

Nouns denoting body parts

Synonyms:

labrocyte; mast cell; mastocyte

Hypernyms ("mast cell" is a kind of...):

somatic cell; vegetative cell (any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes)

Holonyms ("mast cell" is a part of...):

connective tissue (tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments)

 Context examples 

The Fc Epsilon Receptor 1 signaling pathway in mast cells uses multiple core signal paths to achieve its necessary ends.

(Fc Epsilon Receptor I Signaling Pathway BioCarta, NCI Thesaurus/BIOCARTA)

The hydrochloride salt form of olopatadine, a dual action selective histamine H1 receptor antagonist and mast cell stabilizer with anti-allergic activity.

(Olopatadine Hydrochloride, NCI Thesaurus)

There is no evidence of mast cell leukemia or clonal hematologic malignancy.

(Aggressive Systemic Mastocytosis, NCI Thesaurus)

A localized tumor consisting of mature mast cells. (WHO, 2001) — 2003

(Extracutaneous Mastocytoma, NCI Thesaurus)

This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, such as histamine and leukotrienes, which are involved in the allergic process.

(Pemirolast, NCI Thesaurus)

Finally, the researchers found that intestinal biopsies from four children with atopic dermatitis contained more mast cells than those from four children without the condition.

(Scratching the skin primes the gut for allergic reactions to food, mouse study suggests, National Institutes of Health)

In addition, elevated levels of cAMP inhibit release of inflammatory mediators from mast cells.

(Pirbuterol Acetate, NCI Thesaurus)

A dual action selective histamine H1 receptor antagonist and mast cell stabilizer with anti-allergic activity.

(Olopatadine, NCI Thesaurus)

This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process.

(Pemirolast Potassium, NCI Thesaurus)

Moreover activated mast cells and Th2 cells in the lung generate the cytokines interleukin IL-4, IL-13 and tumour necrosis factor (TNF)-alpha.

(Asthma Pathway, NCI Thesaurus/KEGG)