LOCUS (loci)

Pronunciation (US):

(GB):

IPA (US):

Irregular inflected form: loci   

 Dictionary entry overview: What does locus mean? 

• LOCUS (noun)
  The noun LOCUS has 3 senses:

1. the scene of any event or action (especially the place of a meeting)

2. the specific site of a particular gene on its chromosome

3. the set of all points or lines that satisfy or are determined by specific conditions

  Familiarity information: LOCUS used as a noun is uncommon.

 Dictionary entry details 

• LOCUS (noun)

Sense 1

Meaning:

The scene of any event or action (especially the place of a meeting)

Classified under:

Nouns denoting spatial position

Synonyms:

locale; locus; venue

Hypernyms ("locus" is a kind of...):

scene (the place where some action occurs)

Sense 2

Meaning:

The specific site of a particular gene on its chromosome

Classified under:

Nouns denoting spatial position

Hypernyms ("locus" is a kind of...):

site; situation (physical position in relation to the surroundings)

Sense 3

Meaning:

The set of all points or lines that satisfy or are determined by specific conditions

Classified under:

Nouns denoting groupings of people or objects

Context example:

the locus of points equidistant from a given point is a circle

Hypernyms ("locus" is a kind of...):

set ((mathematics) an abstract collection of numbers or symbols)

 Context examples 

Neurogenic locus notch homolog protein 2 (2471 aa, ~265 kDa) is encoded by the human NOTCH2 gene.

(Neurogenic Locus Notch Homolog Protein 2, NCI Thesaurus)

Type 1 neurofibromatosis has dominant inheritance, with a gene locus on the proximal long arm of chromosome 17.

(Neurofibromatosis type 1, NCI Thesaurus)

The range of mutations that have occurred to a gene, or at a specific locus.

(Mutation Spectra, NCI Thesaurus)

A set of genetic loci where each locus contains a mononucleotide (single base pair) repeat sequence.

(Mononucleotide Marker Panel, NCI Thesaurus)

Expression of the allele is altered in non-Hodgkin lymphoma patients by a three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with the MYC gene and the immunoglobulin H locus.

(BCL7A wt Allele, NCI Thesaurus)

Neurogenic locus notch homolog protein 3 (2321 aa, ~244 kDa) is encoded by the human NOTCH3 gene.

(Neurogenic Locus Notch Homolog Protein 3, NCI Thesaurus)

It is often applied more narrowly to the set of alleles present at one or more specific loci.

(Genotype, NCI Dictionary)

A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries a translocation between the IL3 gene on chromosome 5 and the IGH locus on chromosome 14.

(B Lymphoblastic Leukemia/Lymphoma with t(5;14)(q31;q32); IL3-IGH, NCI Thesaurus)

BAT26, a poly(A) tract in MSH2 intron 5, is one example of a BAT locus.

(BAT Locus, NCI Thesaurus)

This allele, which encodes neurogenic locus notch homolog protein 1 protein, plays a role in developmental processes by controlling cell fate decisions.

(NOTCH1 wt Allele, NCI Thesaurus)