LOADED

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does loaded mean? 

• LOADED (adjective)
  The adjective LOADED has 5 senses:

1. filled with a great quantity

2. (of weapons) charged with ammunition

3. (of statements or questions) charged with associative significance and often meant to mislead or influence

4. having an abundant supply of money or possessions of value

5. very drunk

  Familiarity information: LOADED used as an adjective is common.

 Dictionary entry details 

• LOADED (adjective)

Sense 1

Meaning:

Filled with a great quantity

Synonyms:

laden; ladened; loaded

Context example:

'ladened' is not current usage

Similar:

full (containing as much or as many as is possible or normal)

Sense 2

Meaning:

(of weapons) charged with ammunition

Context example:

a loaded gun

Similar:

live (charged with an explosive)

undischarged; unexploded (still capable of exploding or being fired)

Antonym:

unloaded ((of weapons) not charged with ammunition)

Sense 3

Meaning:

(of statements or questions) charged with associative significance and often meant to mislead or influence

Context example:

a loaded question

Similar:

discriminatory; prejudiced (being biased or having a belief or attitude formed beforehand)

Sense 4

Meaning:

Having an abundant supply of money or possessions of value

Synonyms:

affluent; flush; loaded; moneyed; substantial; wealthy

Context example:

a substantial family

Similar:

rich (possessing material wealth)

Sense 5

Meaning:

Very drunk

Synonyms:

besotted; blind drunk; blotto; cockeyed; crocked; fuddled; loaded; pie-eyed; pissed; pixilated; plastered; slopped; sloshed; smashed; soaked; soused; sozzled; squiffy; stiff; tight; wet

Similar:

drunk; gone; inebriated; intoxicated; ripped (stupefied or excited by a chemical substance (especially alcohol))

Domain usage:

argot; cant; jargon; lingo; patois; slang; vernacular (a characteristic language of a particular group (as among thieves))

 Context examples 

Mercedes was riding the loaded sled.

(The Call of the Wild, by Jack London)

A NASA-led team has found evidence that the oversized planet WASP-18b is wrapped in a smothering stratosphere loaded with carbon monoxide and devoid of water.

(WASP-18b Has Smothering Stratosphere Without Water, NASA)

A formulation in which liposomes are loaded with the cytokine interleukin-2 (IL-2).

(Interleukin-2 Liposome, NCI Thesaurus)

Upon administration, hTERT mRNA/survivin peptide-double-loaded autologous dendritic cell vaccine may elicit an immune response against cancer cells expressing hTERT and survivin by activating cytotoxic T-cells (CTLs), natural killer cells (NKs), and B-lymphocytes.

(hTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine, NCI Thesaurus)

Treat every gun as if it were loaded.

(Gun Safety, NIH)

In the clinic, Rosi has serious side effects, but agents other than Rosi or PGE2 could be loaded into the nanoparticles.

(Nanoparticles target, transform fat tissue, NIH)

He had himself picked up the loaded hunting-crop, which was his favourite weapon.

(The Return of Sherlock Holmes, by Sir Arthur Conan Doyle)

A cancer vaccine consisting of autologous dendritic cells (DCs) loaded with CD133-positive autologous brain tumor stem cells (BTSCs) -derived mRNA with potential immunostimulatory and antineoplastic activities.

(Autologous CD133-Positive BTSC mRNA-Pulsed Autologous Dendritic Cell Vaccine, NCI Thesaurus)

Autologous activated T cells, loaded with a bispecific antibody produced by heteroconjugation of anti-CD3 and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, with potential antineoplastic activity.

(EGFRBi-Armed Autologous T Cells, NCI Thesaurus)

The pDox was loaded into the particles through nanometer-sized pores.

(Injectable nanoparticles deliver cancer therapy in mice, NIH)