LINKAGE

Pronunciation (US):

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IPA (US):

 Dictionary entry overview: What does linkage mean? 

• LINKAGE (noun)
  The noun LINKAGE has 4 senses:

1. an associative relation

2. (genetics) traits that tend to be inherited together as a consequence of an association between their genes; all of the genes of a given chromosome are linked (where one goes they all go)

3. a mechanical system of rods or springs or pivots that transmits power or motion

4. the act of linking things together

  Familiarity information: LINKAGE used as a noun is uncommon.

 Dictionary entry details 

• LINKAGE (noun)

Sense 1

Meaning:

An associative relation

Classified under:

Nouns denoting relations between people or things or ideas

Hypernyms ("linkage" is a kind of...):

connectedness; connection; connexion (a relation between things or events (as in the case of one causing the other or sharing features with it))

Hyponyms (each of the following is a kind of "linkage"):

link; nexus (the means of connection between things linked in series)

Derivation:

link (make a logical or causal connection)

Sense 2

Meaning:

(genetics) traits that tend to be inherited together as a consequence of an association between their genes; all of the genes of a given chromosome are linked (where one goes they all go)

Classified under:

Nouns denoting attributes of people and objects

Synonyms:

gene linkage; linkage

Hypernyms ("linkage" is a kind of...):

hereditary pattern; inheritance ((genetics) attributes acquired via biological heredity from the parents)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

Sense 3

Meaning:

A mechanical system of rods or springs or pivots that transmits power or motion

Classified under:

Nouns denoting man-made objects

Hypernyms ("linkage" is a kind of...):

mechanical system (a system of elements that interact on mechanical principles)

Derivation:

link (be or become joined or united or linked)

Sense 4

Meaning:

The act of linking things together

Classified under:

Nouns denoting acts or actions

Hypernyms ("linkage" is a kind of...):

attachment; fastening (the act of fastening things together)

Derivation:

link (connect, fasten, or put together two or more pieces)

 Context examples 

The linkage system in brentuximab vedotin is highly stable in plasma, resulting in cytotoxic specificity for CD30-positive cells.

(Brentuximab vedotin, NCI Thesaurus)

Disulfide linkages are most common in secreted proteins, where proteins are exposed to more oxidizing conditions that are found in the cellular interior.

(Biosynthesis of Cysteine Pathway, NCI Thesaurus/BIOCARTA)

Beta-methyl cyclodextrin is part of a group of cyclic polysaccharides containing 6 to 8 glucose units in alpha-(1,4) linkage.

(Beta-methyl Cyclodextrin, NCI Thesaurus)

A phospholipid with a polar serine found in phosphoester linkage to diacylglycerol.

(Phosphatidylserine, NCI Thesaurus)

Genetic linkage analysis revealed a target DNA region shared by all affected members of a particularly large family.

(Study finds genetic link for rare intestinal cancer, NIH)

A phospholipid with the polar ethanolamine found in phosphoester linkage to diacylglycerol.

(Cephalin, NCI Thesaurus)

Humans lack digestive enzymes to cleave beta-(1,4) linkages and thus cannot absorb glucose from cellulose.

(Cellulose, NCI Thesaurus/CRCH)

Carbenicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall.

(Carbenicillin Potassium, NCI Thesaurus)

An aziridinyl-substituted cyclophosphazene and a putrescence derivative that may cause DNA cross-linkage.

(AZP, NCI Thesaurus)

This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis.

(Carbenicillin, NCI Thesaurus)