LIGATION

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does ligation mean? 

• LIGATION (noun)
  The noun LIGATION has 1 sense:

1. (surgery) tying a duct or blood vessel with a ligature (as to prevent bleeding during surgery)

  Familiarity information: LIGATION used as a noun is very rare.

 Dictionary entry details 

• LIGATION (noun)

Sense 1

Meaning:

(surgery) tying a duct or blood vessel with a ligature (as to prevent bleeding during surgery)

Classified under:

Nouns denoting acts or actions

Hypernyms ("ligation" is a kind of...):

ligature; tying (the act of tying or binding things together)

Domain category:

surgery (the branch of medical science that treats disease or injury by operative procedures)

Hyponyms (each of the following is a kind of "ligation"):

tubal ligation (a sterilization procedure with women; both Fallopian tubes are tied in two places and the tubes removed in between the ligations)

Derivation:

ligate (bind with a bandage or ligature)

 Context examples 

Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.

(Nucleotide Excision Repair, NCI Thesaurus)

This protein plays a role in the modulation of protein ubiquitin ligation.

(E3 Ubiquitin-Protein Ligase SIAH2, NCI Thesaurus)

This dimer stimulates various, and sometimes opposing, cell signaling events in response to ligation of a G protein coupled receptor, such as the beta-adrenergic, adenosine, dopamine, LTB4, and PGE2 receptors, among many others.

(G Beta Gamma, NCI Thesaurus)

In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metalloproteinases and loss of VE-cadherin-mediated adhesion.

(Leukocyte Transendothelial Migration Pathway, NCI Thesaurus/KEGG)

Any physiologic process which occurs in response to ligation of the platelet activating factor receptor, and results in a reduced number of active signaling molecules within the target cell.

(Negative Regulation of Platelet Activating Factor Signaling, NCI Thesaurus)

BCR ligation also activates PTEN opposing PI3K activation of MYC.

(CTCF Pathway, NCI Thesaurus/BIOCARTA)

After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated.

(B Cell Receptor Signaling Pathway, NCI Thesaurus/KEGG)

Following BCR/CD19 ligation, LYN (Src kinase) phosphorylates CD19-Y513, binds to the CD19-SH2 domain and phosphorylates CD19-Y482.

(CD19 Antigen, NCI Thesaurus)

Any physiologic process which occurs in response to ligation of a colony stimulating factor receptor with a cognate ligand, and results in a reduced number of active signaling molecules within the target cell.

(Colony Stimulating Factor Suppression, NCI Thesaurus)

Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation.

(Non-Homologous End-Joining Pathway, NCI Thesaurus/KEGG)