LEWIS

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IPA (US):

• LEWIS (noun)
  The noun LEWIS has 6 senses:

1. United States rock star singer and pianist (born in 1935)

2. United States athlete who won gold medals at the Olympics for his skill in sprinting and jumping (born in 1961)

3. United States explorer and soldier who lead led an expedition from St. Louis to the mouth of the Columbia River (1774-1809)

4. United States labor leader who was president of the United Mine Workers of America from 1920 to 1960 and president of the Congress of Industrial Organizations from 1935 to 1940 (1880-1969)

5. United States novelist who satirized middle-class America in his novel Main Street (1885-1951)

6. English critic and novelist; author of theological works and of books for children (1898-1963)

  Familiarity information: LEWIS used as a noun is common.

• LEWIS (noun)

Sense 1

Meaning:

United States rock star singer and pianist (born in 1935)

Classified under:

Nouns denoting people

Synonyms:

Jerry Lee Lewis; Lewis

Instance hypernyms:

pianist; piano player (a person who plays the piano)

rock star (a famous singer of rock music)

Sense 2

Meaning:

United States athlete who won gold medals at the Olympics for his skill in sprinting and jumping (born in 1961)

Classified under:

Nouns denoting people

Synonyms:

Carl Lewis; Frederick Carleton Lewis; Lewis

Instance hypernyms:

jumper (an athlete who competes at jumping)

sprinter (someone who runs a short distance at top speed)

Sense 3

Meaning:

United States explorer and soldier who lead led an expedition from St. Louis to the mouth of the Columbia River (1774-1809)

Classified under:

Nouns denoting people

Synonyms:

Lewis; Meriwether Lewis

Instance hypernyms:

adventurer; explorer (someone who travels into little known regions (especially for some scientific purpose))

Sense 4

Meaning:

United States labor leader who was president of the United Mine Workers of America from 1920 to 1960 and president of the Congress of Industrial Organizations from 1935 to 1940 (1880-1969)

Classified under:

Nouns denoting people

Synonyms:

John L. Lewis; John Llewelly Lewis; Lewis

Instance hypernyms:

labor leader (a leader of a labor movement)

Sense 5

Meaning:

United States novelist who satirized middle-class America in his novel Main Street (1885-1951)

Classified under:

Nouns denoting people

Synonyms:

Harry Sinclair Lewis; Lewis; Sinclair Lewis

Instance hypernyms:

author; writer (writes (books or stories or articles or the like) professionally (for pay))

Sense 6

Meaning:

English critic and novelist; author of theological works and of books for children (1898-1963)

Classified under:

Nouns denoting people

Synonyms:

C. S. Lewis; Clive Staples Lewis; Lewis

Instance hypernyms:

author; writer (writes (books or stories or articles or the like) professionally (for pay))

 Context examples 

A humanized immunotoxin directed against the Lewis Y antigen conjugated with calicheamicin, a hydrophobic enediyne antibiotic, with potential antineoplastic activity.

(Immunotoxin CMD-193, NCI Thesaurus)

Hu3S193 binds to the protein Lewis(y), which is found on colon, breast, lung, ovary, and prostate cancer cells.

(Hu3S193, NCI Dictionary)

E-Selectin recognizes Lewis X family- or Lewis A family-related sialylated carbohydrate groups.

(E-Selectin, NCI Thesaurus)

MoAb B3 is a murine MoAb that recognizes a Lewis Y carbohydrate antigen present on the surface of many carcinomas.

(In 111 Monoclonal Antibody B3, NCI Thesaurus)

MoAb Hu3S193 recognizes a Lewis Y carbohydrate antigen present on the surface of many carcinomas.

(In 111 Monoclonal Antibody Hu3S193, NCI Thesaurus)

A humanized monoclonal antibody directed against the Lewis Y antigen, a tumor-associated epithelial antigen, with potential antineoplastic activity.

(Monoclonal Antibody Hu3S193, NCI Thesaurus)

A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y.

(LMB-9 immunotoxin, NCI Thesaurus)

LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors.

(LMB-1 immunotoxin, NCI Thesaurus)

A radiolabeled antibody-targeted antineoplastic antibiotic consisting of the enediyne antibiotic calicheamicin conjugated with anti-Lewis Y antibody and labeled with indium In 111.

(Indium In 111-CMD-193, NCI Thesaurus)

Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis.

(BR96-Doxorubicin Immunoconjugate, NCI Thesaurus)