LEFLUNOMIDE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does leflunomide mean? 

• LEFLUNOMIDE (noun)
  The noun LEFLUNOMIDE has 1 sense:

1. an anti-TNF compound (trade name Arava) that is given orally; can slow the progression of rheumatoid arthritis by slowing the proliferation of white blood cells which reduces inflammation in the synovium

  Familiarity information: LEFLUNOMIDE used as a noun is very rare.

 Dictionary entry details 

• LEFLUNOMIDE (noun)

Sense 1

Meaning:

An anti-TNF compound (trade name Arava) that is given orally; can slow the progression of rheumatoid arthritis by slowing the proliferation of white blood cells which reduces inflammation in the synovium

Classified under:

Nouns denoting man-made objects

Synonyms:

Arava; leflunomide

Hypernyms ("leflunomide" is a kind of...):

anti-TNF compound (a class of drugs that block the action of tumor necrosis factor (TNF); used in cases of rheumatoid arthritis because TNF instigates inflammation of the joints)

 Context examples 

As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes.

(Leflunomide, NCI Thesaurus)