LABILE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does labile mean? 

• LABILE (adjective)
  The adjective LABILE has 2 senses:

1. (chemistry, physics, biology) readily undergoing change or breakdown

2. liable to change

  Familiarity information: LABILE used as an adjective is rare.

 Dictionary entry details 

• LABILE (adjective)

Sense 1

Meaning:

(chemistry, physics, biology) readily undergoing change or breakdown

Similar:

reactive (participating readily in reactions)

Domain category:

biological science; biology (the science that studies living organisms)

Sense 2

Meaning:

Liable to change

Context example:

an emotionally labile person

Similar:

imbalanced; unbalanced (being or thrown out of equilibrium)

 Context examples 

They are acid-labile and serologically distinct from alpha- and beta-IFNs.

(Interferon Gamma, NCI Thesaurus)

The development of budotitane was halted due to the rapid loss of its labile groups under physiological conditions.

(Budotitane, NCI Thesaurus)

The gamma or immune IFNs, which are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs.

(Interferon, NCI Thesaurus)

As an alkylating agent, clyclodisone induces the formation of DNA interstrand crosslinks, DNA strand breaks, and alkali-labile lesions in the DNA of some tumor cell lines.

(Cyclodisone, NCI Thesaurus)

This serotype differs from other pathogenic E. coli as it is negative for invasiveness (Sereny test), adheres through E. coli common pilus, and doesn't produce heat stable or heat labile toxins.

(Escherichia coli strain O157:H7, NCI Thesaurus)

Most of the IGF-I in the circulation is bound to IGF-binding protein-3 (IGFBP-3) in a ternary complex with acid-labile subunit (ALS); a smaller fraction is bound to the five other IGFBP.

(Food Intake and Energy Homeostasis Pathway, NCI Thesaurus/BIOCARTA)

Inhibition of GH signal transduction results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and other GH-responsive serum proteins, including IGF binding protein-3 (IGFBP-3) and the acid-labile subunit (ALS), and may inhibit the growth of cancers in which IGF-1 is upregulated.

(Pegvisomant, NCI Thesaurus)

After displacement of the labile oxalate ligand leaving group, the active oxaliplatin derivatives (monoaquo and diaquo DACH platinum) alkylate macromolecules, and form both inter- and intra-strand platinum-DNA crosslinks, thereby inhibiting DNA replication and resulting in cytotoxicity.

(Liposomal Oxaliplatin, NCI Thesaurus)

After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity.

(Oxaliplatin, NCI Thesaurus)