KLOTHO

Pronunciation (US):

(GB):

 Dictionary entry overview: What does Klotho mean? 

• KLOTHO (noun)
  The noun KLOTHO has 1 sense:

1. the Greek goddess of fate who spins the thread of life

  Familiarity information: KLOTHO used as a noun is very rare.

 Dictionary entry details 

• KLOTHO (noun)

Sense 1

Meaning:

The Greek goddess of fate who spins the thread of life

Classified under:

Nouns denoting people

Synonyms:

Clotho; Klotho

Instance hypernyms:

Greek deity (a deity worshipped by the ancient Greeks)

Holonyms ("Klotho" is a member of...):

Moirae; Moirai (any of the three Greek goddesses of fate or destiny; identified with the Roman Parcae and similar to the Norse Norns)

 Context examples 

The results suggest that increasing the presence of GluN2B-containing receptors may be one way that klotho could enhance cognitive skills.

(Longevity gene linked to better brain skills, NIH, US)

This allele, which encodes klotho protein, plays a role in both signal transduction and the modulation of aging.

(KL wt Allele, NCI Thesaurus)

Klotho (1012 aa, ~116 kDa) is encoded by the human KL gene.

(Klotho, NCI Thesaurus)

When klotho mice were treated with a drug that blocked GluN2B-containing receptors, their ability to perform on learning and memory tests was reduced.

(Longevity gene linked to better brain skills, NIH, US)

The researchers caution, however, that additional research is needed to better understand the effects of klotho.

(Longevity gene linked to better brain skills, NIH, US)

Mice genetically engineered to overproduce klotho lived longer and had higher levels of klotho in the brain’s hippocampus, an area that controls some types of learning and memory.

(Longevity gene linked to better brain skills, NIH, US)

The researchers next examined how the klotho protein affects learning and memory in mice.

(Longevity gene linked to better brain skills, NIH, US)

Previous studies found that increased levels of the klotho protein can extend lifespan, whereas disruption of klotho can speed up aging.

(Longevity gene linked to better brain skills, NIH, US)

It’s been unclear, however, whether klotho might also have an effect on cognitive function, which typically declines with age.

(Longevity gene linked to better brain skills, NIH, US)

To examine the potential link between klotho and cognition, Dr. Dena Dubal of the University of California, San Francisco, and her colleagues focused on a Klotho variant called KL-VS.

(Longevity gene linked to better brain skills, NIH, US)