ITRACONAZOLE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does itraconazole mean? 

• ITRACONAZOLE (noun)
  The noun ITRACONAZOLE has 1 sense:

1. an oral antifungal drug (trade name Sporanox) taken for cases of fungal nail disease

  Familiarity information: ITRACONAZOLE used as a noun is very rare.

 Dictionary entry details 

• ITRACONAZOLE (noun)

Sense 1

Meaning:

An oral antifungal drug (trade name Sporanox) taken for cases of fungal nail disease

Classified under:

Nouns denoting man-made objects

Synonyms:

itraconazole; Sporanox

Hypernyms ("itraconazole" is a kind of...):

antifungal; antifungal agent; antimycotic; antimycotic agent; fungicide (any agent that destroys or prevents the growth of fungi)

 Context examples 

By decreasing the tumor vasculature and nutrient supply, itraconazole ultimately inhibits tumor cell growth.

(Itraconazole Dispersion In Polymer Matrix, NCI Thesaurus)

Formulated for both topical and systemic use, itraconazole preferentially inhibits fugal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis.

(Itraconazole, NCI Thesaurus)

Upon oral administration, itraconazole inhibits the enzyme cytochrome P450 lanosterol 14 alpha-demethylase, resulting in a decrease in fungal ergosterol synthesis.

(Itraconazole Dispersion In Polymer Matrix, NCI Thesaurus)

A proprietary oral formulation composed of the poorly soluble, synthetic triazole agent, itraconazole, dispersed in a polymer matrix, with antifungal and potential anti-angiogenic activities.

(Itraconazole Dispersion In Polymer Matrix, NCI Thesaurus)

The solid dispersion of itraconazole in the polymer matrix enhances dissolution of itraconazole in the gastrointestinal tract and increases its bioavailability; this allows for the administration of a much lower dose compared to itraconazole alone.

(Itraconazole Dispersion In Polymer Matrix, NCI Thesaurus)

Although the exact mechanism through which itraconazole inhibits angiogenesis has yet to be fully elucidated, this agent appears to inhibit the Hedgehog (Hh) signaling pathway, cholesterol synthesis and mammalian target of rapamycin (mTOR) signaling in endothelial cells.

(Itraconazole Dispersion In Polymer Matrix, NCI Thesaurus)