IRREVERSIBLY

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does irreversibly mean? 

• IRREVERSIBLY (adverb)
  The adverb IRREVERSIBLY has 1 sense:

1. in an irreversible manner

  Familiarity information: IRREVERSIBLY used as an adverb is very rare.

 Dictionary entry details 

• IRREVERSIBLY (adverb)

Sense 1

Meaning:

In an irreversible manner

Context example:

this old tradition is irreversibly disappearing

Pertainym:

irreversible (incapable of being reversed)

 Context examples 

Fluorine F 18 FEQA irreversibly binds to EGFR, allowing imaging of EGFR-positive tumor cells with positron emission tomography (PET).

(fluorine F 18 FEQA, NCI Thesaurus)

This agent irreversibly binds to the bacterial 30S ribosomal subunit.

(Gentamicin, NCI Thesaurus)

Emetine inhibits protein synthesis in eukaryotic (but not prokaryotic) cells by irreversibly blocking ribosome movement along the mRNA strand and inhibits DNA replication in the early S phase of the cell cycle.

(Emetine Hydrochloride, NCI Thesaurus)

EGFR inhibitor PF-00299804 specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

(EGFR Inhibitor PF-00299804, NCI Thesaurus)

Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells.

(Eflornithine, NCI Thesaurus)

Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling.

(Ibrutinib, NCI Thesaurus)

Deficiencies of lactase, maltase or sucrase-isomaltase usually occur irreversibly and independent of one another.

(Intestinal Disaccharidase Deficiency and Disaccharide Malabsorption, NCI Thesaurus)

Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor.

(Neratinib, NCI Thesaurus)

Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit.

(Netilmicin, NCI Thesaurus)

Neomycin sulfate, an aminoglycoside antibiotic, irreversibly binds to the bacterial 30S subunit proteins and 16S rRNA of ribosome, thereby causing misreading and inhibiting protein synthesis which results in bactericidal effect.

(Neosporin Ophthalmic, NCI Thesaurus)