IRREVERSIBLE

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does irreversible mean? 

• IRREVERSIBLE (adjective)
  The adjective IRREVERSIBLE has 1 sense:

1. incapable of being reversed

  Familiarity information: IRREVERSIBLE used as an adjective is very rare.

 Dictionary entry details 

• IRREVERSIBLE (adjective)

Sense 1

Meaning:

Incapable of being reversed

Context example:

irreversible momentum toward revolution

Similar:

permanent (not capable of being reversed or returned to the original condition)

Antonym:

reversible (capable of reversing or being reversed)

Derivation:

irreversibility (the quality of being irreversible (once done it cannot be changed))

 Context examples 

An irreversible unique number generated from a string of text.

(Hash Value, NCI Thesaurus)

Upon administration, the hypoxia-activated prodrug PR610 is activated in the hypoxic cells within tumors into an irreversible pan-HER inhibitor via a mechanism of action not yet fully elucidated.

(Hypoxia-activated Prodrug PR610, NCI Thesaurus)

A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.

(Ilaprazole, NCI Thesaurus)

In cancer treatment, irreversible enzyme inhibitors may block certain enzymes that cancer cells need to grow and may kill cancer cells.

(Irreversible enzyme inhibitor, NCI Dictionary)

The key steps in the regulation of glycolysis, or any pathway, are those that catalyze the rate-limiting, irreversible steps along the pathway.

(Glycolysis Pathway, NCI Thesaurus/BIOCARTA)

The R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.

(Dexlansoprazole, NCI Thesaurus)

After oral administration, sulindac undergoes extensive biotransformation including irreversible oxidation to sulindac sulfone.

(Exisulind, NCI Thesaurus)

A disorder characterized by irreversible damage to the liver tissue, leading to complete liver failure.

(End Stage Liver Disease, NCI Thesaurus)

An orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic activity.

(EGFR Inhibitor CO-1686, NCI Thesaurus)

A 4-ethylthio-3-methylpyridine analogue of omeprazole with no substituent on the benzimidazole ring, with selective and irreversible proton pump inhibitor activity.

(Disuprazole, NCI Thesaurus)