INTERNALIZATION

Pronunciation (US):

(GB):

 Dictionary entry overview: What does internalization mean? 

• INTERNALIZATION (noun)
  The noun INTERNALIZATION has 1 sense:

1. learning (of values or attitudes etc.) that is incorporated within yourself

  Familiarity information: INTERNALIZATION used as a noun is very rare.

 Dictionary entry details 

• INTERNALIZATION (noun)

Sense 1

Meaning:

Learning (of values or attitudes etc.) that is incorporated within yourself

Classified under:

Nouns denoting cognitive processes and contents

Synonyms:

incorporation; internalisation; internalization

Hypernyms ("internalization" is a kind of...):

acquisition; learning (the cognitive process of acquiring skill or knowledge)

Hyponyms (each of the following is a kind of "internalization"):

introjection ((psychology) unconscious internalization of aspects of the world (especially aspects of persons) within the self in such a way that the internalized representation takes over the psychological functions of the external objects)

introjection ((psychoanalysis) the internalization of the parent figures and their values; leads to the formation of the superego)

Derivation:

internalize (incorporate within oneself; make subjective or personal)

 Context examples 

Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis in GCC-expressing tumor cells.

(Anti-GCC Antibody-Drug Conjugate MLN0264, NCI Thesaurus)

The LF and EF proteins bind to the PA pre-pore, followed by internalization of the entire structure through receptor-mediated endocytosis.

(Anthrax Toxin Pathway, NCI Thesaurus/BIOCARTA)

This causes the internalization of SGN-CD33A, and the release of the cytotoxic moiety SGD-1882.

(Anti-CD33 Antibody-Drug Conjugate SGN-CD33A, NCI Thesaurus)

Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis.

(Anti-CD79B Monoclonal Antibody-MMAE Conjugate DCDS4501A, NCI Thesaurus)

Upon antibody/antigen binding and internalization, the immunoconjugate releases MMAF, which binds to tubulin and inhibits its polymerization.

(Anti-CD19 Antibody-Drug Conjugate SGN-CD19A, NCI Thesaurus)

This prevents hepcidin-induced internalization and degradation of ferroportin, thus decreasing macrophage iron retention.

(PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94, NCI Thesaurus)

In addition, binding of Sym004 to EGFRs causes EGFR internalization and degradation.

(Anti-EGFR Monoclonal Antibody Mixture Sym004, NCI Thesaurus)

After internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and tumor cell apoptosis.

(Anti-AGS-5 Antibody-Drug Conjugate ASG-5ME, NCI Thesaurus)

After antibody-antigen interaction and internalization, the immunoconjugate releases DM4, which binds to tubulin and disrupts microtubule assembly/disassembly dynamics, thereby inhibiting cell division and cell growth of FOLR1-expressing tumor cells.

(Anti-FOLR1-Monoclonal Antibody-Maytansinoid Conjugate IMGN853, NCI Thesaurus)

Upon internalization, the Pseudomonas exotoxin A moiety then inactivates elongation factor 2 (EF-2) through ADP ribosylation, resulting in inhibition of protein synthesis in EP-2-expressing cells.

(Anti-EGP-2 Immunotoxin MOC31-PE, NCI Thesaurus)