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INDOMETHACIN
| Pronunciation (US): |  | (GB): | |
Dictionary entry overview: What does indomethacin mean?
• INDOMETHACIN (noun)
The noun INDOMETHACIN has 1 sense:
1. a nonsteroidal anti-inflammatory drug (trade name Indocin)
Familiarity information: INDOMETHACIN used as a noun is very rare.
Dictionary entry details
Sense 1
Meaning:
A nonsteroidal anti-inflammatory drug (trade name Indocin)
Classified under:
Nouns denoting man-made objects
Synonyms:
Indocin; indomethacin
Hypernyms ("indomethacin" is a kind of...):
nonsteroidal anti-inflammatory; nonsteroidal anti-inflammatory drug; NSAID (an anti-inflammatory drug that does not contain steroids)
Meronyms (substance of "indomethacin"):
acetic acid; ethanoic acid (a colorless pungent liquid widely used in manufacturing plastics and pharmaceuticals)
Context examples
Indomethacin is a non-selective, reversible, and competitive inhibitor of cyclooxygenases 1 and 2, thereby blocking the conversion of arachidonic acid into prostaglandin precursors.
(Indomethacin Sodium, NCI Thesaurus)
In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis.
(Indomethacin, NCI Thesaurus)
The sodium salt of indomethacin, a methylated indole derivative with anti-inflammatory, analgesic-antipyretic and tocolytic effects.
(Indomethacin Sodium, NCI Thesaurus)
As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines.
(Indomethacin, NCI Thesaurus)
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