HYPERCHOLESTEROLEMIA

Pronunciation (US):

(GB):

 Dictionary entry overview: What does hypercholesterolemia mean? 

• HYPERCHOLESTEROLEMIA (noun)
  The noun HYPERCHOLESTEROLEMIA has 1 sense:

1. the presence of an abnormal amount of cholesterol in the cells and plasma of the blood; associated with the risk of atherosclerosis

  Familiarity information: HYPERCHOLESTEROLEMIA used as a noun is very rare.

 Dictionary entry details 

• HYPERCHOLESTEROLEMIA (noun)

Sense 1

Meaning:

The presence of an abnormal amount of cholesterol in the cells and plasma of the blood; associated with the risk of atherosclerosis

Classified under:

Nouns denoting stable states of affairs

Synonyms:

hypercholesteremia; hypercholesterolemia

Hypernyms ("hypercholesterolemia" is a kind of...):

symptom ((medicine) any sensation or change in bodily function that is experienced by a patient and is associated with a particular disease)

Hyponyms (each of the following is a kind of "hypercholesterolemia"):

familial hypercholesterolemia (congenital disorder characterized by high levels of cholesterol and early development of atherosclerosis)

 Context examples 

An acetate salt form of lapaquistat, a squalene synthase inhibitor investigated for the treatment of hypercholesterolemia.

(Lapaquistat Acetate, NCI Thesaurus)

This agent has not yet been shown to reduce deaths associated with hypercholesterolemia.

(Anacetrapib, NCI Thesaurus)

Mutations in the gene result in autosomal dominant disorder, familial hypercholesterolemia.

(LDLR wt Allele, NCI Thesaurus)

Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.

(Low Density Lipoprotein Receptor, NCI Thesaurus/LocusLink)

This mouse model is prone to the development of fatty lesions in the aorta similar to atheromatous plaque in humans, as well as hyperglycemia, hyperinsulinemia, hypercholesterolemia and non-insulin-dependent diabetes mellitus in response to a high fat diet.

(C57BL/6 Mouse, NCI Thesaurus)

The mice become metabolically hyperactive and, even when consuming a diet very high in fat and sugar, are able to resist metabolic diseases such as obesity, hypertension, hypercholesterolemia, diabetes, and atherosclerosis, said the study’s lead researcher Filip Swirski, Ph.D., an associate professor at Harvard Medical School and Massachusetts General Hospital, Boston.

(Some gut cells slow down metabolism, accelerate cardiovascular disease, National Institutes of Health)