HUNTINGTON

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does Huntington mean? 

• HUNTINGTON (noun)
  The noun HUNTINGTON has 4 senses:

1. United States physician who first described Huntington's chorea

2. American revolutionary leader who signed the Declaration of Independence and was president of the Continental Congress (1731-1796)

3. United States railroad executive who built the western section of the first United States transcontinental railroad (1821-1900)

4. a city of western West Virginia on the Ohio river at the mouth of the Kanawha

  Familiarity information: HUNTINGTON used as a noun is uncommon.

 Dictionary entry details 

• HUNTINGTON (noun)

Sense 1

Meaning:

United States physician who first described Huntington's chorea

Classified under:

Nouns denoting people

Synonyms:

George Huntington; Huntington

Instance hypernyms:

doc; doctor; Dr.; MD; medico; physician (a licensed medical practitioner)

Sense 2

Meaning:

American revolutionary leader who signed the Declaration of Independence and was president of the Continental Congress (1731-1796)

Classified under:

Nouns denoting people

Synonyms:

Huntington; Samuel Huntington

Instance hypernyms:

American Revolutionary leader (a nationalist leader in the American Revolution and in the creation of the United States)

Sense 3

Meaning:

United States railroad executive who built the western section of the first United States transcontinental railroad (1821-1900)

Classified under:

Nouns denoting people

Synonyms:

Collis Potter Huntington; Huntington

Instance hypernyms:

businessman; man of affairs (a person engaged in commercial or industrial business (especially an owner or executive))

Sense 4

Meaning:

A city of western West Virginia on the Ohio river at the mouth of the Kanawha

Classified under:

Nouns denoting spatial position

Instance hypernyms:

city; metropolis; urban center (a large and densely populated urban area; may include several independent administrative districts)

Holonyms ("Huntington" is a part of...):

Mountain State; W.V.; West Virginia; WV (a state in east central United States)

 Context examples 

There are a few hypotheses for the connection between these aggregates and the neurodegeneration observed in Huntington's disease.

(Inhibition of Huntington's Disease Pathway, NCI Thesaurus/BIOCARTA)

Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN).

(Huntington's Disease Pathway, NCI Thesaurus/KEGG)

Alteration in the expression of this gene is associated with the development of Huntington's disease.

(MIR132 wt Allele, NCI Thesaurus)

While it has no known role in oncogenesis, MIR132 plays a role in the development of Huntington's disease.

(MIR132 Gene, NCI Thesaurus)

If one of your parents has Huntington's disease, you have a 50 percent chance of getting it.

(Huntington's Disease, NIH: National Institute of Neurological Disorders and Stroke)

These proteins, such as huntingtin in Huntington’s disease and tau in some dementias, form ‘aggregates’ that can cause irreversible damage to nerve cells in the brain.

(Blood pressure drug shows promise for treating Parkinson’s and dementia in animal studies, University of Cambridge)

Expression of the allele is decreased in both Alzheimer's and Huntington disease.

(BDNF wt Allele, NCI Thesaurus)

It is seen in patients with Huntington's disease.

(Chorea, NCI Thesaurus)

Genetic polymorphism of this gene is associated with Huntington disease.

(HTT wt Allele, NCI Thesaurus)

Huntington disease is an example of a genetic disorder in which the biological mechanism for this phenomenon has been well documented.

(Genetic Anticipation, NCI Dictionary)