HSV-1

 Dictionary entry overview: What does HSV-1 mean? 

• HSV-1 (noun)
  The noun HSV-1 has 1 sense:

1. a herpes virus that causes oral herpes

  Familiarity information: HSV-1 used as a noun is very rare.

 Dictionary entry details 

• HSV-1 (noun)

Sense 1

Meaning:

A herpes virus that causes oral herpes

Classified under:

Nouns denoting animals

Synonyms:

herpes simplex 1; HS1; HSV-1; HSV-I

Hypernyms ("HSV-1" is a kind of...):

herpes simplex; herpes simplex virus (a herpes virus that affects the skin and nervous system)

 Context examples 

Upon intracerebral administration, oncolytic HSV-1 G207 preferentially replicates within glioma cells, which may elicit tumor-specific systemic immune and cytotoxic T lymphocyte (CTL) responses in addition to direct cytopathic effects.

(G207, NCI Thesaurus)

There is no cure for infection with HSV-1 and HSV2, viruses that can cause recurrent outbreaks of cold sores and genital sores in humans.

(Glutamine suppresses herpes in mice and guinea pigs, National Institutes of Health)

Upon administration, the recombinant human GM-CSF HSV-1 selectively infects and replicates in tumor cells, thereby inducing tumor cell lysis.

(Oncolytic Herpes Simplex Virus-1-encoding GM-CSF, NCI Thesaurus)

A gene therapy agent containing an attenuated, replication-competent, genetically engineered mutant form of the Herpes simplex virus 1 (HSV-1) strain KOS with potential antineoplastic activity.

(Oncolytic HSV-1 rRp450, NCI Thesaurus)

NV1020 is constructed from the herpes simplex virus 1 (HSV-1) by the deletion of a single copy of the gamma (1)34.5 gene and the substitution of the UL23 region of the thymidine kinase (tk) gene with a DNA fragment from HSV-2, thereby resulting in a replication-competent, attenuated virus.

(NV1020, NCI Thesaurus)

In addition, the HSV-1 gene UL39, encoding the viral ribonucleotide reductase large subunit infected cell protein 6 (ICP6), has been inactivated through the insertion of the Escherichia coli lacZ gene.

(G207, NCI Thesaurus)

To test this hypothesis, scientists from National Institute of Allergy and Infectious Diseases (NIAID) infected mice with HSV-1 and guinea pigs with HSV-2 and randomly assigned the animals to different treatment groups.

(Glutamine suppresses herpes in mice and guinea pigs, National Institutes of Health)

Therefore, CPA can become activated in the presence of rRp450 and exert its antineoplastic effect. rRp450 is deleted for the HSV-1 gene UL39, encoding the viral ribonucleotide reductase large subunit infected cell protein 6 (ICP6), thereby disrupting the activity of viral ribonucleotide reductase and resulting in the inhibition of nucleotide metabolism and viral DNA synthesis in nondividing cells but not in dividing cells.

(Oncolytic HSV-1 rRp450, NCI Thesaurus)

Derived from wild-type HSV-1 strain F, this agent has been neuroattenuated by deletions in both copies of the gamma34.5 gene, the major determinant of HSV neurovirulence.

(G207, NCI Thesaurus)

Results showed that mice that received glutamine were less likely to have HSV-1 reactivation than those that did not, and similarly, guinea pigs that received glutamine were less likely to have recurrent outbreaks of HSV-2 than those that did not receive the supplement.

(Glutamine suppresses herpes in mice and guinea pigs, National Institutes of Health)