HISTONE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does histone mean? 

• HISTONE (noun)
  The noun HISTONE has 1 sense:

1. a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids

  Familiarity information: HISTONE used as a noun is very rare.

 Dictionary entry details 

• HISTONE (noun)

Sense 1

Meaning:

A simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids

Classified under:

Nouns denoting substances

Hypernyms ("histone" is a kind of...):

simple protein (a protein that yields only amino acids when hydrolyzed)

 Context examples 

Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides.

(BET Inhibitor GSK525762, NCI Thesaurus)

Upon administration, the BET inhibitor TEN-010 binds to the acetylated lysine recognition motifs found in the bromodomain of BET proteins, which prevents the interaction between BET proteins and acetylated histones.

(BET Inhibitor TEN-010, NCI Thesaurus)

This gene may play a role in both histone acetylation and transcriptional regulation.

(BRD3 Gene, NCI Thesaurus)

This allele, which encodes bromodomain-containing protein 3, may be involved in both transcriptional regulation and histone acetylation.

(BRD3 wt Allele, NCI Thesaurus)

Upon administration, the BET bromodomains 2, 3 and 4 inhibitor OTX015 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides.

(BET Bromodomains 2/3/4 Inhibitor OTX015, NCI Thesaurus)

A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity.

(Belinostat, NCI Thesaurus)

Most cases of DMG are caused by a specific mutation in histone genes.

(Scientists find promising drug combination against lethal childhood brain cancers, National Institutes of Health)

This gene plays a role in transcriptional regulation and histone acetylation.

(ATF2 Gene, NCI Thesaurus)

Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro.

(BARD1 Pathway, NCI Thesaurus/BIOCARTA)

This protein may play a role in the regulation of both histone acetylation and transcription.

(Bromodomain-Containing Protein 3, NCI Thesaurus)