HISTOCOMPATIBILITY COMPLEX

Pronunciation (US):

(GB):

 Dictionary entry overview: What does histocompatibility complex mean? 

• HISTOCOMPATIBILITY COMPLEX (noun)
  The noun HISTOCOMPATIBILITY COMPLEX has 1 sense:

1. a family of fifty or more genes on the sixth human chromosome that code for proteins on the surfaces of cells and that play a role in the immune response

  Familiarity information: HISTOCOMPATIBILITY COMPLEX used as a noun is very rare.

 Dictionary entry details 

• HISTOCOMPATIBILITY COMPLEX (noun)

Sense 1

Meaning:

A family of fifty or more genes on the sixth human chromosome that code for proteins on the surfaces of cells and that play a role in the immune response

Classified under:

Nouns denoting groupings of people or objects

Hypernyms ("histocompatibility complex" is a kind of...):

category; class; family (a collection of things sharing a common attribute)

 Context examples 

This allele, which encodes major histocompatibility complex class I-related gene protein, is involved in antigen presentation in the gut.

(MR1 wt Allele, NCI Thesaurus)

This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.

(Cerivastatin, NCI Thesaurus)

Major histocompatibility complex class I-related gene protein (341 aa, ~39 kDa) is encoded by the human MR1 gene.

(Major Histocompatibility Complex Class I-Related Gene Protein, NCI Thesaurus)

In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses.

(Leishmaniasis Infection Pathway, NCI Thesaurus/KEGG)

The major histocompatibility complex (MHC) molecules are made of 2 chains, alpha and beta.

(Immunoglobulin Domain, NCI Thesaurus)

This protein is the beta subunit of the major histocompatibility complex, class II DR protein, which is expressed primarily in lymphoid cells and functions to present antigens for CD4+ T lymphocytes.

(HLA-DR51 Antigen, NCI Thesaurus)

This protein plays a role in immune responses and is a key component of major histocompatibility complex class I molecules.

(Beta-2-Microglobulin Protein, NCI Thesaurus)

LAG-3 is a member of the immunoglobulin superfamily (IgSF) and binds to major histocompatibility complex (MHC) class II.

(Anti-LAG-3 Monoclonal Antibody BMS-986016, NCI Thesaurus)

They are interleukin-2-activated NK cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation.

(Murine Lymphokine Activated Killer Cells, NLM, Medical Subject Headings)

A hereditary immunodeficiency disorder caused by the absence of major histocompatibility complex class II expression.

(Bare Lymphocyte Syndrome, NCI Thesaurus)