HETEROZYGOSITY

Pronunciation (US):

(GB):

 Dictionary entry overview: What does heterozygosity mean? 

• HETEROZYGOSITY (noun)
  The noun HETEROZYGOSITY has 1 sense:

1. the state of being heterozygous; having two different alleles of the same gene

  Familiarity information: HETEROZYGOSITY used as a noun is very rare.

 Dictionary entry details 

• HETEROZYGOSITY (noun)

Sense 1

Meaning:

The state of being heterozygous; having two different alleles of the same gene

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("heterozygosity" is a kind of...):

state (the way something is with respect to its main attributes)

Antonym:

homozygosity (the state of being homozygous; having two identical alleles of the same gene)

Derivation:

heterozygous (having dissimilar alleles at corresponding chromosomal loci)

 Context examples 

FRAG1 resides in a chromosome region implicated in Beckwith-Wiedemann syndrome and frequent loss of heterozygosity in multiple tumor types.

(FGF Receptor Activating Protein 1, NCI Thesaurus)

This allele, which encodes loss of heterozygosity 11 chromosomal region 2 gene A protein, is putatively involved in the inhibition of cell cycle progression.

(LOH11CR2A wt Allele, NCI Thesaurus)

A software application that performs copy number and loss of heterozygosity (LOH) analysis on data from Affymetrix mapping genotyping microarrays.

(Copy Number Analysis Tool, NCI Thesaurus)

Loss of heterozygosity of the CASP7 gene has been detected in several types of solid tumors.

(CASP7 wt Allele, NCI Thesaurus)

The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors.

(Axin 2, NCI Thesaurus)

When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor suppressor gene.

(Loss of Heterozygosity, NCI Dictionary)

The NEURL gene exhibits loss of heterozygosity in astrocytomas.

(NEURL wt Allele, NCI Thesaurus)

The appearance of this condition has been limited to the loss of allelic heterozygosity at the 11q13 locus on the long arm of chromosome 11.

(Multiple Endocrine Neoplasia Type 1, NLM, Medical Subject Headings)

AT heterozygosity is estimated to occur in more than 2% of the U.S. population; heterozygotes exhibit increased radiation sensitivity and are at increased risk for several types of cancer.

(Ataxia Telangiectasia Syndrome, NCI Thesaurus)

The loss of heterozygosity on chromosome 19p (where the responsible gene LKB1 is located) suggests that the increased risk of malignancy may be due to malignant transformation from hamartoma to adenocarcinoma. —2002

(Peutz-Jeghers Polyp, NCI Thesaurus)