HAPLOTYPE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does haplotype mean? 

• HAPLOTYPE (noun)
  The noun HAPLOTYPE has 1 sense:

1. (genetics) a combination of alleles (for different genes) that are located closely together on the same chromosome and that tend to be inherited together

  Familiarity information: HAPLOTYPE used as a noun is very rare.

 Dictionary entry details 

• HAPLOTYPE (noun)

Sense 1

Meaning:

(genetics) a combination of alleles (for different genes) that are located closely together on the same chromosome and that tend to be inherited together

Classified under:

Nouns denoting body parts

Hypernyms ("haplotype" is a kind of...):

combination (a collection of things that have been combined; an assemblage of separate parts or qualities)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

 Context examples 

The majority of haplotypes of the CYP2D6*2 allele exhibit SNPs (g.2850C>T; g.4180G>C) in exons 6 and 9 that result in R296C and S486T coding changes.

(CYP2D6*2 Allele, NCI Thesaurus)

There are multiple haplotypes of the CYP1A2*1 allele.

(CYP1A2*1 Allele, NCI Thesaurus)

Four other haplotypes of the CYP2D6*1 allele exhibit SNPs that have no effect on the enzymatic activity of the corresponding cytochrome P450 2D6*10 proteins.

(CYP2D6*1 Allele, NCI Thesaurus)

There are multiple haplotypes of this allele.

(CYP2C19*1 Allele, NCI Thesaurus)

The Lewis rat has a MHC haplotype of RT1A'.

(Lewis, Rat Strain, NCI Thesaurus)

A donor who has only one haplotype in common with the recipient.

(Haploidentical, NCI Thesaurus)

The DBA/1 mouse has a q H2 haplotype and carries the Cdh23^ahl mutation that results in progressive hearing loss after 10 months of age.

(DBA/1 Mouse, NCI Thesaurus)

Three other haplotypes of this allele exhibit a deletion (g.-2665delTG) and/or a SNP (g.-1188T>C) in the 5'- flanking region upstream of the gene.

(CYP2C9*1 Allele, NCI Thesaurus)

An assay intended to study interindividual variations in whole-genome or candidate gene, single-nucleotide polymorphism (SNP) maps, haplotype markers, or alterations in gene expression or inactivation that may be correlated with pharmacological function and therapeutic response.

(Pharmacogenomic Test, Food and Drug Administration)

It is based on the premise that regions adjacent to a gene of interest are transmitted through the generations along with that gene and can be identified by the specific pattern of markers (haplotypes) that they contain, so that detection of haplotypes that are shared more frequently among groups of individuals recruited for a disease or trait can be used to locate specific genes.

(Linkage Disequilibrium Mapping, NCI Thesaurus)