GUANOSINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does guanosine mean? 

• GUANOSINE (noun)
  The noun GUANOSINE has 1 sense:

1. a nucleoside component of DNA; composed of guanine and deoxyribose

  Familiarity information: GUANOSINE used as a noun is very rare.

 Dictionary entry details 

• GUANOSINE (noun)

Sense 1

Meaning:

A nucleoside component of DNA; composed of guanine and deoxyribose

Classified under:

Nouns denoting substances

Synonyms:

deoxyguanosine; guanosine

Hypernyms ("guanosine" is a kind of...):

nucleoside (a glycoside formed by partial hydrolysis of a nucleic acid)

 Context examples 

A nucleoside reverse transcriptase inhibitor analog of guanosine.

(Abacavir, NCI Thesaurus)

An acyclic guanosine analog with activity against herpes simplex virus (HSV).

(Buciclovir, NCI Thesaurus)

AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis.

(AVN944, NCI Thesaurus)

A nucleoside reverse transcriptase inhibitor prodrug analog of guanosine.

(Amdoxovir, NCI Thesaurus)

A measurement of the cyclic guanosine 3,5-monophosphate in a biological specimen.

(Cyclic Guanosine Monophosphate Measurement, NCI Thesaurus/CDISC)

A dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity.

(DNA Methyltransferase Inhibitor SGI-110, NCI Thesaurus)

Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases.

(Pentaerythritol Tetranitrate, NCI Thesaurus)

Agents that inhibit Inosine 5'-Phosphate Dehydrogenase, an regulatory enzyme of guanosine triphosphate biosynthesis, causing possible inhibition of cell proliferation and malignancy.

(Inosine 5'-Phosphate Dehydrogenase Inhibitor, NCI Thesaurus)

GTP Binding is a molecular interaction between specific proteins (containing a GTP binding site) and guanosine 5-prime triphosphate during diverse cellular processes, such as RNA synthesis, translation, signal transduction, and cytoskeletal assembly.

(GTP Binding, NCI Thesaurus)

Subsequently, a low dose of a synthetic acyclic guanosine analogue such as valacyclovir (VCV) or ganciclovir (GCV) is given, which may preferentially kill tumor cells containing the adenoviral vector and overexpressing HSV-tk.

(Adenoviral Vector Encoding HSV Thymidine Kinase, NCI Thesaurus)