GLUCOCORTICOID

Pronunciation (US):

(GB):

 Dictionary entry overview: What does glucocorticoid mean? 

• GLUCOCORTICOID (noun)
  The noun GLUCOCORTICOID has 1 sense:

1. a steroid hormone that is produced by the adrenal cortex of animals; affects functioning of gonads and has anti-inflammatory activity

  Familiarity information: GLUCOCORTICOID used as a noun is very rare.

 Dictionary entry details 

• GLUCOCORTICOID (noun)

Sense 1

Meaning:

A steroid hormone that is produced by the adrenal cortex of animals; affects functioning of gonads and has anti-inflammatory activity

Classified under:

Nouns denoting substances

Hypernyms ("glucocorticoid" is a kind of...):

endocrine; hormone; internal secretion (the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect)

adrenal cortical steroid; corticoid; corticosteroid (a steroid hormone produced by the adrenal cortex or synthesized; administered as drugs they reduce swelling and decrease the body's immune response)

Hyponyms (each of the following is a kind of "glucocorticoid"):

corticosterone (secreted by the adrenal cortex; involved in regulating water and electrolyte balance in the body)

Pediapred; prednisolone; Prelone (a glucocorticoid (trade names Pediapred or Prelone) used to treat inflammatory conditions)

Deltasone; Liquid Pred; Meticorten; Orasone; prednisone (a dehydrogenated analogue of cortisol (trade names Orasone or Deltasone or Liquid Pred or Meticorten); used as an anti-inflammatory drug in the treatment of arthritis and as an immunosuppressant)

 Context examples 

The disodium salt of the 21-phosphate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.

(Betamethasone Sodium Phosphate, NCI Thesaurus)

The team uncovered similar rhythms for the hormones aldosterone, which regulates sodium excretion from the kidney, and glucocorticoids, which help regulate metabolism.

(How the body regulates salt levels, NIH)

Betamethasone dipropionate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression.

(Betamethasone Dipropionate, NCI Thesaurus)

A synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities.

(Betamethasone, NCI Thesaurus)

As a glucocorticoid agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppression of immune and inflammatory responses.

(Clindamycin/Hydrocortisone Lotion, NCI Thesaurus)

Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression.

(Clobetasol Propionate, NCI Thesaurus)

This gene is involved in ligand-activated transcriptional regulation and mutations in the gene are associated with glucocorticoid resistance.

(NR3C1 Gene, NCI Thesaurus)

Mutations in the gene are a primary cause of glucocorticoid resistance, or cortisol resistance.

(NR3C1 wt Allele, NCI Thesaurus)

PGC-1a is a coactivator for many factors including, CBP, Scr-1, PPARa, glucocorticoid receptor, thyroid hormone receptor, several orphan receptors, and MEF2.

(PGC1a Regulation Pathway, NCI Thesaurus/BIOCARTA)

Glucocorticoids, widely used as anti-inflammatory drugs, increase TLR2 activation by H. influenzae through the NIK/I-kB kinase pathway, while they repress the p38 dependent activation of NF-kB.

(NFKB Activation Pathway, NCI Thesaurus/BIOCARTA)