GENE MUTATION

Pronunciation (US):

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 Dictionary entry overview: What does gene mutation mean? 

• GENE MUTATION (noun)
  The noun GENE MUTATION has 1 sense:

1. (genetics) a mutation due to an intramolecular reorganization of a gene

  Familiarity information: GENE MUTATION used as a noun is very rare.

 Dictionary entry details 

• GENE MUTATION (noun)

Sense 1

Meaning:

(genetics) a mutation due to an intramolecular reorganization of a gene

Classified under:

Nouns denoting natural events

Synonyms:

gene mutation; point mutation

Hypernyms ("gene mutation" is a kind of...):

chromosomal mutation; genetic mutation; mutation ((genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism)

Domain category:

genetic science; genetics (the branch of biology that studies heredity and variation in organisms)

 Context examples 

The frequency with which a test yields a true positive result among individuals who actually have the disease or the gene mutation in question.

(Diagnostic Sensitivity, NCI Dictionary)

The frequency with which a test yields a true negative result among individuals who do not have the disease or the gene mutation in question.

(Diagnostic Specificity, NCI Dictionary)

Most people with CML have a gene mutation (change) called the Philadelphia chromosome.

(Chronic Myeloid Leukemia, NIH: National Cancer Institute)

The research focused on the case of a woman who carried a gene mutation known to cause early-onset Alzheimer’s.

(Unique case of disease resistance reveals possible Alzheimer’s treatment, National Institutes of Health)

A rare genetic syndrome most often caused by BRAF gene mutations.

(Cardiofaciocutaneous Syndrome, NCI Thesaurus)

These cancers often occur at an early age, and may indicate the presence of a gene mutation that increases the risk of cancer.

(Familial cancer, NCI Dictionary)

Some genetic brain disorders are due to random gene mutations or mutations caused by environmental exposure, such as cigarette smoke.

(Genetic Brain Disorders, NIH)

The acute myeloid leukemia is usually an acute megakaryoblastic leukemia, and is associated with GATA1 gene mutation.

(Myeloid Leukemia Associated with Down Syndrome, NCI Thesaurus)

These gene mutations are independent predictors of poor prognosis.

(Myelodysplastic Syndrome with Gene Mutation, NCI Thesaurus)

Gene mutations are associated with familial hyperproinsulinemia.

(INS wt Allele, NCI Thesaurus)