FLUVASTATIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does fluvastatin mean? 

• FLUVASTATIN (noun)
  The noun FLUVASTATIN has 1 sense:

1. least expensive statin drug (trade name Lescol); usually taken orally at bedtime

  Familiarity information: FLUVASTATIN used as a noun is very rare.

 Dictionary entry details 

• FLUVASTATIN (noun)

Sense 1

Meaning:

Least expensive statin drug (trade name Lescol); usually taken orally at bedtime

Classified under:

Nouns denoting man-made objects

Synonyms:

fluvastatin; Lescol

Hypernyms ("fluvastatin" is a kind of...):

lipid-lowering medication; lipid-lowering medicine; statin; statin drug (a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase)

 Context examples 

Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.

(Fluvastatin, NCI Thesaurus)

Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.

(Fluvastatin Sodium, NCI Thesaurus)

Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.

(Fluvastatin, NCI Thesaurus)

Through the inhibition of mevalonate synthesis, statins, like fluvastatin, have been shown to inhibit the production of dolichol, geranylpyrophosphate (GPP) and farnesylpyrophosphate (FPP) and the isoprenylation of the intracellular G-proteins Ras and Rho, which may result in antiangiogenic, apoptotic, and antimetastatic effects in susceptible tumor cell populations.

(Fluvastatin Sodium, NCI Thesaurus)