EXTRACELLULAR

Pronunciation (US):

(GB):

 Dictionary entry overview: What does extracellular mean? 

• EXTRACELLULAR (adjective)
  The adjective EXTRACELLULAR has 1 sense:

1. located or occurring outside a cell or cells

  Familiarity information: EXTRACELLULAR used as an adjective is very rare.

 Dictionary entry details 

• EXTRACELLULAR (adjective)

Sense 1

Meaning:

Located or occurring outside a cell or cells

Classified under:

Relational adjectives (pertainyms)

Context example:

extracellular fluid

Domain category:

biological science; biology (the science that studies living organisms)

Antonym:

intracellular (located or occurring within a cell or cells)

Pertainym:

cell ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals)

 Context examples 

EGFR, a member of the epidermal growth factor family of extracellular protein ligands, is overexpressed on the cell surfaces of various solid tumors.

(Anti-EGFR Monoclonal Antibody GT-MAB 5.2-GEX, NCI Thesaurus)

EGFL7, a vascular-restricted extracellular matrix protein which is upregulated during angiogenesis and which regulates vascular development, may be overexpressed on the cell surfaces of various solid tumor cell types.

(Anti-EGFL7 Monoclonal Antibody MEGF0444A, NCI Thesaurus)

Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and encoded by a multigene family.

(Mitogen-Activated Protein Kinase, NCI Thesaurus)

This gene plays a role in cell migration, inflammation and the regulation of extracellular matrix remodeling.

(MMP1 Gene, NCI Thesaurus)

Anti-CD70 fully human monoclonal antibody MDX-1411 selectivity binds to the extracellular domain of CD70, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells.

(Anti-CD70 Monoclonal Antibody MDX-1411, NCI Thesaurus)

Known as extracellular vesicles, these bubble-like particles are produced by many kinds of cells and are thought to transport molecules from one cell to another.

(Vesicles released by bacteria may reduce the spread of HIV in human tissue, National Institutes of Health)

PG545 inhibits the cleavage of heparan sulfate from cell surface proteoglycan by heparanase and thus inhibits the neovascularization induced by interaction between heparan sulfate and other extracellular matrix proteins.

(Angiogenesis/Heparanase Inhibitor PG545, NCI Thesaurus)

Any apoptotic process triggered by inadequate or inappropriate adherence to substrate, such as may occur after disruption of the interactions between normal epithelial cells and the extracellular matrix.

(Anoikis, NCI Thesaurus)

The anti-CD70 antibody moiety of the anti-CD70 antibody-drug conjugate MDX-1203 selectively binds to the extracellular domain of CD70 on tumor cell surfaces.

(Anti-CD70 Antibody-Drug Conjugate MDX-1203, NCI Thesaurus)

A defucosylated, humanized IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity.

(Anti-CD70 Monoclonal Antibody ARGX-110, NCI Thesaurus)