EXONUCLEASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does exonuclease mean? 

• EXONUCLEASE (noun)
  The noun EXONUCLEASE has 1 sense:

1. a nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid

  Familiarity information: EXONUCLEASE used as a noun is very rare.

 Dictionary entry details 

• EXONUCLEASE (noun)

Sense 1

Meaning:

A nuclease that releases one nucleotide at a time (serially) beginning at one of a nucleic acid

Classified under:

Nouns denoting substances

Hypernyms ("exonuclease" is a kind of...):

nuclease (general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units)

 Context examples 

A conserved amino acid sequence (Tyr-(X)3-Asp) in DNA polymerases that is required for 3' > 5' exonuclease activity.

(EXO III Motif, NCI Thesaurus)

This allele, which encodes exonuclease 1 protein, plays a role in mismatch repair and recombination.

(EXO1 wt Allele, NCI Thesaurus)

Exonuclease 1, encoded by the EXO1 gene, is a 88-kD protein with 5-prime to 3-prime double strand DNA exonuclease activity as well as an RNase H activity.

(Exonuclease 1, NCI Thesaurus/LocusLink)

Exosome complex exonuclease RRP44 (958 aa, ~109 kDa) is encoded by the human DIS3 gene.

(Exosome Complex Exonuclease RRP44, NCI Thesaurus)

Most of the proteins in the RISC (with the exception of Ago2 and Dicer have not been identified) but likely contain endonuclease, helicase, exonuclease and homology scanning activity.

(Dicer Pathway, NCI Thesaurus/BIOCARTA)

A conserved amino acid sequence (Asn-(X)3-Phe-Asp) in DNA polymerases that is required for 3' > 5' exonuclease activity.

(EXO II Motif, NCI Thesaurus)

This allele, which encodes exosome complex exonuclease RRP44 protein, plays a role in the modulation of ribosomal RNA processing.

(DIS3 wt Allele, NCI Thesaurus)

A conserved amino acid sequence (Asp-X-Glu) in DNA polymerases that is required for 3' > 5' exonuclease activity.

(EXO I Motif, NCI Thesaurus)

The enzyme complex both facilitates DNA synthesis by acting as a polymerase and exhibits exonuclease activity that degrades single stranded DNA in the 3' to 5' direction.

(DNA Polymerase Delta, NCI Thesaurus)

They also possess exonuclease activity and therefore function in DNA repair.

(DNA-directed DNA Polymerase, NLM, Medical Subject Headings)