ERGOSTEROL

Pronunciation (US):

(GB):

 Dictionary entry overview: What does ergosterol mean? 

• ERGOSTEROL (noun)
  The noun ERGOSTEROL has 1 sense:

1. a plant sterol that is converted into vitamin D by ultraviolet radiation

  Familiarity information: ERGOSTEROL used as a noun is very rare.

 Dictionary entry details 

• ERGOSTEROL (noun)

Sense 1

Meaning:

A plant sterol that is converted into vitamin D by ultraviolet radiation

Classified under:

Nouns denoting substances

Hypernyms ("ergosterol" is a kind of...):

steroid alcohol; sterol (any of a group of natural steroid alcohols derived from plants or animals; they are waxy insoluble substances)

Holonyms ("ergosterol" is a substance of...):

calciferol; cholecalciferol; D; ergocalciferol; viosterol; vitamin D (a fat-soluble vitamin that prevents rickets)

 Context examples 

Upon oral administration, itraconazole inhibits the enzyme cytochrome P450 lanosterol 14 alpha-demethylase, resulting in a decrease in fungal ergosterol synthesis.

(Itraconazole Dispersion In Polymer Matrix, NCI Thesaurus)

Formulated for both topical and systemic use, itraconazole preferentially inhibits fugal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis.

(Itraconazole, NCI Thesaurus)

Enzyme inhibition by this agent leads to a decrease in ergosterol pool and therefore disturbs synthesis of fungal cell membrane, thereby increasing cell membrane permeability and promoting loss of essential intracellular elements.

(Isavuconazole, NCI Thesaurus)

Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.

(Ketoconazole, NCI Thesaurus)

By preventing ergosterol synthesis and causing accumulation of squalene, this agent increases cell membrane permeability, cell leakage and eventually cell lysis.

(Liranaftate, NCI Thesaurus)

This prevents the synthesis of ergosterol which is a crucial component of the fungal cell membrane.

(Parconazole, NCI Thesaurus)

This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane.

(Oxiconazole, NCI Thesaurus)

This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells.

(Naftifine Hydrochloride, NCI Thesaurus)

Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase, which catalyzes conversion of lanosterol to ergosterol, an essential component of the fungal cell wall.

(Econazole, NCI Thesaurus)

Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability which leads to a loss of essential intracellular components.

(Econazole Nitrate, NCI Thesaurus)