ENDOTOXIN

Pronunciation (US):

(GB):

 Dictionary entry overview: What does endotoxin mean? 

• ENDOTOXIN (noun)
  The noun ENDOTOXIN has 1 sense:

1. a toxin that is confined inside the microorganisms and is released only when the microorganisms are broken down or die

  Familiarity information: ENDOTOXIN used as a noun is very rare.

 Dictionary entry details 

• ENDOTOXIN (noun)

Sense 1

Meaning:

A toxin that is confined inside the microorganisms and is released only when the microorganisms are broken down or die

Classified under:

Nouns denoting substances

Hypernyms ("endotoxin" is a kind of...):

toxin (a poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species)

Antonym:

exotoxin (a toxin that is secreted by microorganisms into the surrounding medium)

 Context examples 

This allele, which encodes interleukin-1 receptor-associated kinase-like 2 protein, plays a role both in interleukin-1-induced up-regulation of the transcription factor NF-kappa B and in regulation of responsiveness to bacterial endotoxins.

(IRAK2 wt Allele, NCI Thesaurus)

In response to endotoxin, macrophages secrete MIP2, a protein with affinity for heparin and a potent chemotactic agent for polymorphonuclear leukocytes that causes a localized inflammatory reaction.

(Macrophage Inflammatory Protein 2, Alpha, NCI Thesaurus)

This allele, which encodes interleukin-1 receptor-associated kinase 1 protein, is involved both in interleukin-1-induced up-regulation of the transcription factor NF-kappa B and in regulation of responsiveness to bacterial endotoxins.

(IRAK1 wt Allele, NCI Thesaurus)

An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity.

(Lipopolysaccharide, NCI Thesaurus)

Upon bacterial infections, the lipid component (Lipid A) of endotoxin contributes to its toxicity, while the polysaccharide components contribute to immunogenicity.

(Endotoxin, NCI Thesaurus)

The tetrasodium salt of a synthetic analogue of the lipid A portion of the endotoxin lipopolysaccharide (LPS) with potential immunomodulating activity.

(Eritoran Tetrasodium, NCI Thesaurus)

A family of CC-motif cytokines that are produced by macrophages in response to endotoxin exposure.

(Macrophage Inflammatory Protein, NCI Thesaurus)

A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4 (TLR4) agonist, with potential immunostimulatory activity.

(Monophosphoryl Lipid A, NCI Thesaurus)

An antiserum raised against endotoxins of Escherichia coli J5 strain with potential antibacterial activity.

(J5 Antiserum, NCI Thesaurus)

A proprietary vaccine adjuvant composed of the inorganic compound aluminum phosphate mixed with 3-deacylated monophosphoryl lipid A, a derivate of the bacterial endotoxin.

(AS04 Adjuvant, NCI Thesaurus)