DYSPLASIA

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does dysplasia mean? 

• DYSPLASIA (noun)
  The noun DYSPLASIA has 1 sense:

1. abnormal development (of organs or cells) or an abnormal structure resulting from such growth

  Familiarity information: DYSPLASIA used as a noun is very rare.

 Dictionary entry details 

• DYSPLASIA (noun)

Sense 1

Meaning:

Abnormal development (of organs or cells) or an abnormal structure resulting from such growth

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("dysplasia" is a kind of...):

abnormalcy; abnormality (an abnormal physical condition resulting from defective genes or developmental deficiencies)

Hyponyms (each of the following is a kind of "dysplasia"):

aplasia (failure of some tissue or organ to develop)

fibrous dysplasia of bone (a disturbance in which bone that is undergoing lysis is replaced by an abnormal proliferation of fibrous tissue resulting in bone lesions or skin lesions)

hypertrophy (abnormal enlargement of a body part or organ)

hyperplasia (abnormal increase in number of cells)

hypoplasia (underdevelopment of an organ because of a decrease in the number of cells)

anaplasia (loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor)

Derivation:

dysplastic (relating to or evidencing dysplasia)

 Context examples 

Mutation of the gene is associated with both spondyloepimetaphyseal dysplasia Missouri type and metaphyseal anadysplasia type 1.

(MMP13 wt Allele, NCI Thesaurus)

Severe dysplasia, disruption of normal architecture, increased mitotic activity, loss of cellular polarity

(Mouse Islet Cell Adenocarcinoma, NCI Thesaurus/MMHCC)

It is characterized by skeletal dysplasia and short stature.

(Mucopolysaccharidosis Type IVB, NCI Thesaurus)

Also called fibrocystic breast changes, fibrocystic breast disease, and mammary dysplasia.

(Benign breast disease, NCI Dictionary)

There is evidence supporting the idea that the Barrett adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy.

(Barrett Adenocarcinoma, NCI Thesaurus)

It is characterized by prominent serration of the glands and the presence of generalized low-grade dysplasia.

(Appendix Traditional Serrated Adenoma, NCI Thesaurus)

The concept encompasses size, shape, and organization of cell architecture specific for dysplasia, cancer in situ, inflammatory atypia, and preneoplastic states associated with regenerative changes in tissue.

(Atypical Regeneration, NCI Thesaurus)

Useful in assessing for developmental dysplasia of the hip, this test is performed when the thigh is pushed posteriorly and the hip is adducted.

(Barlow's Maneuver, NCI Thesaurus)

The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia.

(Myelodysplastic syndrome, NCI Thesaurus/WHO)

A myelodysplastic syndrome characterized by neutropenia or thrombocytopenia and dysplasia restricted to neutrophil or megakaryocytic cell lines.

(Myelodysplastic Syndrome, Unclassifiable, NCI Thesaurus)