DOWN SYNDROME

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does Down syndrome mean? 

• DOWN SYNDROME (noun)
  The noun DOWN SYNDROME has 1 sense:

1. a congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation

  Familiarity information: DOWN SYNDROME used as a noun is very rare.

 Dictionary entry details 

• DOWN SYNDROME (noun)

Sense 1

Meaning:

A congenital disorder caused by having an extra 21st chromosome; results in a flat face and short stature and mental retardation

Classified under:

Nouns denoting stable states of affairs

Synonyms:

Down's syndrome; Down syndrome; mongolianism; mongolism; trisomy 21

Hypernyms ("Down syndrome" is a kind of...):

birth defect; congenital abnormality; congenital anomaly; congenital defect; congenital disorder (a defect that is present at birth)

trisomy (chrosomal abnormality in which there is one more than the normal number of chromosomes in a cell)

 Context examples 

The HMGN1 gene is overexpressed in Down syndrome.

(HMGN1 wt Allele, NCI Thesaurus)

Down syndrome is a chromosomal disorder.

(Genetic Disorders, NIH: National Library of Medicine)

With support and treatment, many people with Down syndrome live happy, productive lives.

(Down Syndrome, NIH: National Institute of Child Health and Human Development)

Acute myeloid leukemia or myelodysplastic syndrome occurring in children with Down syndrome.

(Myeloid Leukemia Associated with Down Syndrome, NCI Thesaurus)

Myeloid neoplasms occurring in individuals with Down syndrome.

(Myeloid Proliferations Related to Down Syndrome, NCI Thesaurus)

Mutations in the gene may be associated with autism or Down syndrome.

(NCAM2 wt Allele, NCI Thesaurus)

Translocations may lead to medical problems such as leukemia, breast cancer, schizophrenia, muscular dystrophy, and Down syndrome.

(Chromosomal Translocation Process, NCI Dictionary)

These cause conditions such as Down syndrome and Rett syndrome.

(Developmental Disabilities, NIH: National Institute of Child Health and Human Development)

Chromosome found in a trisomic state in the cells of persons with Down syndrome.

(Chromosome 21, NIH CRISP Thesaurus)

Down syndrome occurs in approximately 1:700 live births.

(Down Syndrome, NCI Thesaurus)