DISULFIRAM

Pronunciation (US):

(GB):

 Dictionary entry overview: What does disulfiram mean? 

• DISULFIRAM (noun)
  The noun DISULFIRAM has 1 sense:

1. a drug (trade name Antabuse) used in the treatment of alcoholism; causes nausea and vomiting if alcohol is ingested

  Familiarity information: DISULFIRAM used as a noun is very rare.

 Dictionary entry details 

• DISULFIRAM (noun)

Sense 1

Meaning:

A drug (trade name Antabuse) used in the treatment of alcoholism; causes nausea and vomiting if alcohol is ingested

Classified under:

Nouns denoting man-made objects

Synonyms:

Antabuse; disulfiram

Hypernyms ("disulfiram" is a kind of...):

medicament; medication; medicinal drug; medicine ((medicine) something that treats or prevents or alleviates the symptoms of disease)

 Context examples 

A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram.

(Ditiocarb, NCI Thesaurus)

Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol metabolite acetaldehyde into acetic acid.

(Disulfiram, NCI Thesaurus)

In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations.

(Copper Gluconate, NCI Thesaurus)