DEPLETION

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does depletion mean? 

• DEPLETION (noun)
  The noun DEPLETION has 2 senses:

1. the act of decreasing something markedly

2. the state of being depleted

  Familiarity information: DEPLETION used as a noun is rare.

 Dictionary entry details 

• DEPLETION (noun)

Sense 1

Meaning:

The act of decreasing something markedly

Classified under:

Nouns denoting acts or actions

Hypernyms ("depletion" is a kind of...):

decrease; diminution; reduction; step-down (the act of decreasing or reducing something)

Hyponyms (each of the following is a kind of "depletion"):

consumption; expenditure; using up (the act of consuming something)

exhaustion (the act of exhausting something entirely)

drain (a gradual depletion of energy or resources)

Derivation:

deplete (use up (resources or materials))

Sense 2

Meaning:

The state of being depleted

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("depletion" is a kind of...):

temporary state (a state that continues for a limited time)

Hyponyms (each of the following is a kind of "depletion"):

salt depletion (loss of salt from the body without replacement (loss by vomiting or profuse perspiration or urination or diarrhea) thus upsetting the electrolyte balance)

Derivation:

deplete (use up (resources or materials))

 Context examples 

Depletion of the wild-type allele contributes to the pathogenesis of several cancers; including: neural cancers, melanoma, hematopoietic cancers and several epithelial cancers.

(CHD5 wt Allele, NCI Thesaurus)

Emfolin sodium competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, depletion of nucleotide pools, and inhibition of DNA, RNA and protein synthesis.

(Emofolin Sodium, NCI Thesaurus)

Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA.

(Fluorouracil, NCI Thesaurus)

Since glutathione is critical in protecting cells against oxidative stress, its depletion results in free radical-induced apoptosis.

(Gamma-Glutamylcysteine Synthetase Inhibitor, NCI Thesaurus)

If C5 is adequately synthesized, its rapid depletion may result in a functional deficiency.

(C5 Deficiency, NCI Thesaurus)

If C3 is adequately synthesized, its rapid depletion may result in a functional deficiency.

(C3 Deficiency, NCI Thesaurus)

Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.

(Anthracycline Antineoplastic Antibiotic, NCI Thesaurus)

Upon administration, anti-CD45 monoclonal antibody binds to leukocyte surface-expressed CD45, which may result in the transient depletion of circulating leukocytes including circulating T cell depletion (TCD).

(anti-CD45 monoclonal antibody, NCI Thesaurus)

Depletion of stem cells in the bone marrow that results in the lack of production of hematopoietic cells.

(Bone Marrow Aplasia, NCI Thesaurus)

When co-administered with alkylating agent melphalan, which utilizes amino acid transport systems for cellular uptake, depletion of glutamine by AGA appeared to facilitate melphalan uptake and enhance its cytotoxicity.

(Glutaminase-Asparaginase, NCI Thesaurus)