DEOXYTHYMIDINE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does deoxythymidine mean? 

• DEOXYTHYMIDINE (noun)
  The noun DEOXYTHYMIDINE has 1 sense:

1. a nucleoside component of DNA; composed of thymine and deoxyribose

  Familiarity information: DEOXYTHYMIDINE used as a noun is very rare.

 Dictionary entry details 

• DEOXYTHYMIDINE (noun)

Sense 1

Meaning:

A nucleoside component of DNA; composed of thymine and deoxyribose

Classified under:

Nouns denoting substances

Synonyms:

deoxythymidine; thymidine

Hypernyms ("deoxythymidine" is a kind of...):

nucleoside (a glycoside formed by partial hydrolysis of a nucleic acid)

 Context examples 

A deoxythymidine analog with activity against herpes simplex virus.

(Edoxudine, NCI Thesaurus)

Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

(Pemetrexed, NCI Thesaurus)

Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

(Pemetrexed disodium, NCI Thesaurus)

Subsequently, the noncytotoxic prodrug 5-fluorocytosine (5-FC) is administered systemically and is deaminated by CD in FCU1- transduced tumor cells into 5-fluorouracil (5-FU), which is then directly metabolized to 5-fluoro-uridine monophosphate (5-FUMP) by UPRT; 5-FUMP may then be further transformed to 5-fluoro-deoxyuridine monophosphate (5-FdUMP), an irreversible inhibitor of thymidylate synthase and, so, DNA synthesis through deprivation of deoxythymidine triphosphate (dTTP). 5-FU and its active metabolites may then selectively kill tumor cells, avoiding toxicity in nonmalignant cells.

(MVA-FCU1 TG4023, NCI Thesaurus)