DENATURED

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does denatured mean? 

• DENATURED (adjective)
  The adjective DENATURED has 1 sense:

1. changed in nature or natural quality

  Familiarity information: DENATURED used as an adjective is very rare.

 Dictionary entry details 

• DENATURED (adjective)

Sense 1

Meaning:

Changed in nature or natural quality

Synonyms:

denatured; denaturised; denaturized

Context example:

denatured alcohol

Similar:

changed (made or become different in nature or form)

 Context examples 

The dsDNA molecules are heat denatured, and then quickly cooled.

(Conformation Dependent Mutation Detection, NCI Thesaurus/OSP)

Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells.

(Heinz Body, NLM, Medical Subject Headings)

The determination of the amount of Heinz bodies (denatured hemoglobin) present in a sample.

(Heinz-Ehrlich Body Measurement, NCI Thesaurus)

A humanized, affinity-matured IgG1k antibody directed against denatured collagens (I-IV) with potential antiangiogenic and antineoplastic activities.

(Anti-Denatured Collagen Monoclonal Antibody TRC093, NCI Thesaurus)

Next, the crosslinks are broken, the proteins are removed and the purified DNA is amplified, denatured and labeled with a fluorescent tag.

(ChIP-On-Chip, NCI Thesaurus)

First, a denatured DNA sample is treated with bisulfite which converts non-methylated cytosine to uracil.

(Bisulfite Sequencing, NCI Thesaurus)

RNA extracted from a sample was denatured and separated by slab gel electrophoresis, then blotted on to a nitrocellulose or nylon sheet and hybridized with labeled DNA or RNA that is complementary to the desired RNA, whose presence is subsequently indicated by autoradiography or other visualization techniques.

(Northern Blotting, NCI Thesaurus)

Anti-denatured collagen recombinant monoclonal antibody TRC093 binds to multiple epitopes on denatured collagens, inhibiting proteolytic collagen-mediated signaling in the extracellular matrix (ECM) that is important to tumor angiogenesis, tumor growth, and metastasis.

(Anti-Denatured Collagen Monoclonal Antibody TRC093, NCI Thesaurus)

The labeled, denatured DNA fragments are applied to a DNA microarray where they can hybridize to their complementary DNA sequence.

(ChIP-On-Chip, NCI Thesaurus)

The epitopes on denatured collagen bound by this antibody are considered cryptic because, in vivo, they are accessible only on the subendothelial basement membrane of tumors or in normal tissues undergoing neovascularization.

(Anti-Denatured Collagen Monoclonal Antibody TRC093, NCI Thesaurus)