DEMYELINATION

Pronunciation (US):

(GB):

 Dictionary entry overview: What does demyelination mean? 

• DEMYELINATION (noun)
  The noun DEMYELINATION has 1 sense:

1. loss of the myelin covering of some nerve fibers resulting in their impaired function

  Familiarity information: DEMYELINATION used as a noun is very rare.

 Dictionary entry details 

• DEMYELINATION (noun)

Sense 1

Meaning:

Loss of the myelin covering of some nerve fibers resulting in their impaired function

Classified under:

Nouns denoting stable states of affairs

Hypernyms ("demyelination" is a kind of...):

degenerative disorder (condition leading to progressive loss of function)

Holonyms ("demyelination" is a part of...):

disseminated multiple sclerosis; disseminated sclerosis; MS; multiple sclerosis (a chronic progressive nervous disorder involving loss of myelin sheath around certain nerve fibers)

 Context examples 

A central nervous system disorder caused by demyelination within the central basis pontis of the brain.

(Central Pontine Myelinolysis, NCI Thesaurus)

It is characterized by perivascular demyelination.

(Acute Disseminated Encephalomyelitis, NCI Thesaurus)

It is characterized by brain hemorrhage, vascular necrosis and demyelination.

(Acute Hemorrhagic Leukoencephalitis, NCI Thesaurus)

Charcot-Marie-Tooth disease caused by mutations in the PMP22 gene (mapped to chromosome 17), resulting in peripheral nerve demyelination.

(Charcot-Marie-Tooth Disease Type 1A, NCI Thesaurus)

A progressive autoimmune disorder affecting the central nervous system resulting in demyelination.

(Multiple Sclerosis, NCI Thesaurus)

Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier.

(Experimental Allergic Encephalomyelitis, NCI Thesaurus)

It results in demyelination.

(Acute Infective Polyneuritis, NCI Thesaurus)

Spongy degeneration of central nervous system , spongy degeneration of white matter a rare hereditary form of leukodystrophy of early onset in which widespread demyelination and vacuolation of cerebral white matter gives it a spongy appearance; there is mental retardation, megalocephaly, atony of neck muscles, limb spasticity, and blindness, with death in infancy.

(Canavan Disease, NICHD)