DEAMINATE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does deaminate mean? 

• DEAMINATE (verb)
  The verb DEAMINATE has 1 sense:

1. remove the amino radical (usually by hydrolysis) from an amino compound; to perform deamination

  Familiarity information: DEAMINATE used as a verb is very rare.

 Dictionary entry details 

• DEAMINATE (verb)

Present simple: I / you / we / they deaminate    ... he / she / it deaminates   
Past simple: deaminated   
Past participle: deaminated   
-ing form: deaminating   

Sense 1

Meaning:

Remove the amino radical (usually by hydrolysis) from an amino compound; to perform deamination

Classified under:

Verbs of size, temperature change, intensifying, etc.

Synonyms:

deaminate; deaminize

Hypernyms (to "deaminate" is one way to...):

alter; change; modify (cause to change; make different; cause a transformation)

Sentence frame:

Somebody ----s something

Derivation:

deamination (removal of the amino radical from an amino acid or other amino compound)

 Context examples 

Homocysteine condenses with serine to form cystathionine, which is deaminated and hydrolyzed to form cysteine and alpha-ketobutyrate.

(Biosynthesis of Cysteine Pathway, NCI Thesaurus/BIOCARTA)

After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis.

(Flucytosine, NCI Thesaurus)

Following oral administration of ER 5-FC, the 5-FC is deaminated to its active metabolite 5-fluorouracil (5-FU). 5-FU replaces uracil during RNA synthesis, which consequently inhibits downstream protein synthesis.

(Extended Release Flucytosine, NCI Thesaurus)

Subsequently, the noncytotoxic prodrug 5-fluorocytosine (5-FC) is administered systemically and is deaminated by CD in FCU1- transduced tumor cells into 5-fluorouracil (5-FU), which is then directly metabolized to 5-fluoro-uridine monophosphate (5-FUMP) by UPRT; 5-FUMP may then be further transformed to 5-fluoro-deoxyuridine monophosphate (5-FdUMP), an irreversible inhibitor of thymidylate synthase and, so, DNA synthesis through deprivation of deoxythymidine triphosphate (dTTP). 5-FU and its active metabolites may then selectively kill tumor cells, avoiding toxicity in nonmalignant cells.

(MVA-FCU1 TG4023, NCI Thesaurus)

Upon administration of fluorine F 18 5-fluoro-2-deoxycytidine ([F-18]-FdCyd), the FdCyd moiety is phosphorylated by deoxycytidine kinase to 5-fluoro-2'-deoxycytidylate (FdCMP) and deaminated by deoxycytidylate (dCMP) deaminase, an enzyme overexpressed by tumor cells, to 5-fluoro-2-deoxyuridine monophosphate (FdUMP).

(Fluorine F 18 5-Fluoro-2-deoxycytidine, NCI Thesaurus)