DE NOVO

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does de novo mean? 

• DE NOVO (adverb)
  The adverb DE NOVO has 1 sense:

1. from the beginning

  Familiarity information: DE NOVO used as an adverb is very rare.

 Dictionary entry details 

• DE NOVO (adverb)

Sense 1

Meaning:

From the beginning

Domain category:

Latin (any dialect of the language of ancient Rome)

 Context examples 

Any substance that inhibits dihydroorotate reductase, an enzyme required for de novo biosynthesis of pyrimidine.

(Dihydroorotate Dehydrogenase Inhibitor, NCI Thesaurus)

Cannot initiate a chain de novo.

(DNA-directed DNA Polymerase, NCI Thesaurus)

This allele, which encodes DNA (cytosine-5)-methyltransferase 3B protein, plays a role in de novo methylation.

(DNMT3B wt Allele, NCI Thesaurus)

It may arise de novo or as a malignant transformation of a pre-existing poroma.

(Eccrine Porocarcinoma, NCI Thesaurus)

Any substance that inhibits dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential reaction for de novo glycine and purine synthesis.

(Dihydrofolate reductase inhibitor, NCI Thesaurus)

Dideazatetrahydrofolic acid inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation.

(Dideaza-5,6,7,8-Tetrahydrofolic Acid, NCI Thesaurus)

By replacing guanine, dezaguanine incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death.

(Dezaguanine, NCI Thesaurus)

This allele, which encodes dihydroorotate dehydrogenase, mitochondrial protein, is involved in de novo pyrimidine biosynthesis.

(DHODH wt Allele, NCI Thesaurus)

Dichloroallyl lawsone inhibits mitochondrial dihydroorotate dehydrogenase (DHOD), an enzyme that catalyzes the only redox step in de novo pyrimidine biosynthesis, and nucleotide (RNA and DNA) biosynthesis.

(Dichloroallyl Lawsone, NCI Thesaurus)

In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis.

(Mercaptopurine, NCI Thesaurus)