CYTOTOXICITY

Pronunciation (US):

(GB):

 Dictionary entry overview: What does cytotoxicity mean? 

• CYTOTOXICITY (noun)
  The noun CYTOTOXICITY has 1 sense:

1. the degree to which something is toxic to living cells

  Familiarity information: CYTOTOXICITY used as a noun is very rare.

 Dictionary entry details 

• CYTOTOXICITY (noun)

Sense 1

Meaning:

The degree to which something is toxic to living cells

Classified under:

Nouns denoting quantities and units of measure

Hypernyms ("cytotoxicity" is a kind of...):

toxicity (the degree to which something is poisonous)

 Context examples 

Administration of monoclonal antibody CO17-1A (Mab C017-1A) elicits an antibody-dependent cell-mediated cytotoxicity.

(Monoclonal Antibody CO17-1A, NCI Thesaurus)

Monoclonal antibody Ch14.18 binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells.

(monoclonal antibody Ch14.18, NCI Thesaurus)

MoAb D6.12 has been shown to induce antibody-dependent cell-mediated cytotoxicity (ADCC).

(Monoclonal Antibody D6.12, NCI Thesaurus)

Vaccination with a monoclonal antibody GD2 anti-idiotype vaccine produces an immunoglobulin response against GD2 with subsequent destruction of GD2 positive tumor cells via antibody-dependent cellular cytotoxicity (ADCC).

(Monoclonal Antibody GD2 Anti-Idiotype Vaccine, NCI Thesaurus)

Following binding, monoclonal antibody Hu3S193 triggers an antibody-dependent cell-mediated cytotoxicity in cells expressing Lewis Y antigen.

(Monoclonal Antibody Hu3S193, NCI Thesaurus)

Monoclonal antibody 14G2A binds to the ganglioside GD2 and induces antibody-dependent cell mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells.

(Monoclonal Antibody 14G2A, NCI Thesaurus)

In addition, this agent may induce antibody-dependent cell-mediated cytotoxicity (ADCC) against CCR4-positive T cells.

(Mogamulizumab, NCI Thesaurus)

A melanoma monoclonal antibody, subclass IgG2A, may have potential use as a diagnostic agent and, therapeutically, may induce macrophage-mediated cytotoxicity against antibody-bound melanoma cells.

(Melanoma Monoclonal Antibody hIgG2A, NCI Thesaurus)

Many antineoplastic agents cause cytotoxicity by inducing microtubular bundle formation irreversibly.

(Microtubule Bundle, NCI Thesaurus)

Although the exact mechanism through which this agent induces apoptosis is unknown, it may involve antibody-dependent cellular cytotoxicity (ADCC) or complement-mediated cytotoxicity (CMC).

(Milatuzumab, NCI Thesaurus)