CYTOTOXIC T CELL

 Dictionary entry overview: What does cytotoxic T cell mean? 

• CYTOTOXIC T CELL (noun)
  The noun CYTOTOXIC T CELL has 1 sense:

1. T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it

  Familiarity information: CYTOTOXIC T CELL used as a noun is very rare.

 Dictionary entry details 

• CYTOTOXIC T CELL (noun)

Sense 1

Meaning:

T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it

Classified under:

Nouns denoting body parts

Synonyms:

CD8 cell; CD8 T cell; cytotoxic T cell; killer cell; killer T cell

Hypernyms ("cytotoxic T cell" is a kind of...):

T cell; T lymphocyte (a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells)

 Context examples 

Also called cytotoxic T cell and killer T cell.

(cytotoxic T lymphocyte, NCI Dictionary)

Re-introduction of ex vivo-expanded HER2-specific T cells may enhance the cytotoxic T cell response against tumor cells overexpressing HER2, resulting in inhibition of tumor growth.

(Ex Vivo-Expanded HER2-Specific T Cells, NCI Thesaurus)

Mice with a disrupted CD2 gene are largely normal and appear to have a normal immune system, but CD2 on cytotoxic T cells may assist in interaction with target cells.

(Cytotoxic T Cell Surface Pathway, NCI Thesaurus/BIOCARTA)

A cell that acts in a similar manner to a cytotoxic T cell and must be activated like a cytotoxic T cell.

(Activated Natural Killer Cell, NCI Thesaurus)

This may lead to the induction of cytotoxic T cell immune and antibody-mediated immune responses against melanoma cells expressing gp75. gp75, a pigmentation-associated antigen, is expressed in melanosomes of human melanocytes and melanomas.

(Flanvotumab, NCI Thesaurus)

Strong CD8 cytotoxic T cell responses may be induced after prolonged immunization with fowlpox virus vaccines and have been associated with tumor regression.

(Fowlpox Virus Vaccine Vector, NCI Thesaurus)

Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.

(Oncolytic Adenovirus Encoding GM-CSF, NCI Thesaurus)

In addition, GM-CSF attracts dendritic cells (DCs) and may stimulate a cytotoxic T cell response against tumor cells, which results in immune-mediated tumor cell death.

(Oncolytic Herpes Simplex Virus-1-encoding GM-CSF, NCI Thesaurus)

Upon administration, MUC1 peptide-poly-ICLC adjuvant vaccine may induce the host immune system to mount a cytotoxic T cell response against MUC1-expressing tumor cells.

(MUC1 Peptide-Poly-ICLC Vaccine, NCI Thesaurus)

Upon administration, expressed PSMA may stimulate a cytotoxic T cell response against tumor cells that express PSMA, resulting in tumor cell lysis.

(Mouse Prostate-Specific Membrane Antigen Plasmid DNA Vaccine, NCI Thesaurus)