CYTOTOXIC DRUG

Pronunciation (US):

(GB):

 Dictionary entry overview: What does cytotoxic drug mean? 

• CYTOTOXIC DRUG (noun)
  The noun CYTOTOXIC DRUG has 1 sense:

1. any drug that has a toxic effect on cells; commonly used in chemotherapy to inhibit the proliferation of cancerous cells

  Familiarity information: CYTOTOXIC DRUG used as a noun is very rare.

 Dictionary entry details 

• CYTOTOXIC DRUG (noun)

Sense 1

Meaning:

Any drug that has a toxic effect on cells; commonly used in chemotherapy to inhibit the proliferation of cancerous cells

Classified under:

Nouns denoting man-made objects

Hypernyms ("cytotoxic drug" is a kind of...):

medicament; medication; medicinal drug; medicine ((medicine) something that treats or prevents or alleviates the symptoms of disease)

Hyponyms (each of the following is a kind of "cytotoxic drug"):

antineoplastic; antineoplastic drug; cancer drug (any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function)

 Context examples 

IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.

(IAP Inhibitor HGS1029, NCI Thesaurus)

AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.

(IAP Inhibitor AT-406, NCI Thesaurus)

Basic research to understand the mechanisms that cells use to avoid being killed by cytotoxic drugs.

(Investigation of Mechanisms of Drug Resistance, NCI Thesaurus)

Leukoregulin shows tumor growth inhibitory activity and enhances membrane permeability and the uptake of cytotoxic drugs by tumors cells without affecting these processes in normal cells.

(Leukoregulin, NCI Thesaurus)

A folate receptor-targeting cytotoxic drug conjugate consisting of a folate vitamin analogue linked to a vinca alkaloid microtubule destabilizing agent with potential antineoplastic activity.

(Folate Receptor-Targeted Vinca Alkaloid EC0489, NCI Thesaurus)

Inhibition of the efflux pump by this agent leads to a retention of the cytotoxic drug resulting in increased intracellular drug concentrations, thereby enhancing cytotoxicity.

(Dofequidar Fumarate, NCI Thesaurus)

This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.

(AEG35156, NCI Thesaurus)

Causes include nephrotoxins, cytotoxic drugs, and antibiotics.

(Acute Renal Failure with Tubular Necrosis, NCI Thesaurus)

An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin.

(BR96-Doxorubicin Immunoconjugate, NCI Thesaurus)

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors.

(Antitumor Drug Screening Assay, NLM, Medical Subject Headings)