CYCLOOXYGENASE-2

 Dictionary entry overview: What does cyclooxygenase-2 mean? 

• CYCLOOXYGENASE-2 (noun)
  The noun CYCLOOXYGENASE-2 has 1 sense:

1. an enzyme that makes prostaglandins that cause inflammation and pain and fever

  Familiarity information: CYCLOOXYGENASE-2 used as a noun is very rare.

 Dictionary entry details 

• CYCLOOXYGENASE-2 (noun)

Sense 1

Meaning:

An enzyme that makes prostaglandins that cause inflammation and pain and fever

Classified under:

Nouns denoting substances

Synonyms:

Cox-2; cyclooxygenase-2

Context example:

the beneficial effects of NSAIDs result from their ability to block Cox-2

Hypernyms ("cyclooxygenase-2" is a kind of...):

Cox; cyclooxygenase (either of two related enzymes that control the production of prostaglandins and are blocked by aspirin)

 Context examples 

Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins.

(Etoricoxib, NCI Thesaurus)

This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).

(Interleukin-17, NCI Thesaurus/LocusLink)

Cyclooxygenase-2 inhibitors are being studied in the prevention of colon polyps, and as anticancer drugs.

(Cyclooxygenase-2 inhibitor, NCI Dictionary)

In addition, this agent may inhibit cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin synthesis and prostaglandin-mediated inflammatory processes.

(Eicosapentaenoic Acid, NCI Thesaurus)

Also called cyclooxygenase-2 and prostaglandin-endoperoxide synthase 2.

(COX-2, NCI Dictionary)

Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins.

(Apricoxib, NCI Thesaurus)

Some tumors have high levels of cyclooxygenase-2 and blocking its activity may reduce tumor growth.

(Cyclooxygenase-2, NCI Dictionary)

This in turn modulates the expression of downstream target genes that are upregulated in a variety of cancer cell types, including inducible nitric oxide synthase, cyclooxygenase-2, vascular endothelial growth factor and the anti-apoptotic protein survivin.

(Lyophilized Black Raspberry Saliva Substitute, NCI Thesaurus)

This inhibitory activity modulates the expression of downstream target genes that are upregulated in a variety of cancer cell types, including inducible nitric oxide synthase, cyclooxygenase-2, vascular endothelial growth factor and the anti-apoptotic protein survivin.

(Lyophilized Black Raspberry Lozenge, NCI Thesaurus)

Upon mucosal application, the anthocyanins from the gel penetrate the oral mucosa and are able to modulate expression of certain proapoptotic and terminal differentiation genes, and reduce the expression of epithelial cyclooxygenase-2 (COX-2) protein.

(Freeze-dried Black Raspberry Bioadhesive Gel, NCI Thesaurus)