CYCLOOXYGENASE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does cyclooxygenase mean? 

• CYCLOOXYGENASE (noun)
  The noun CYCLOOXYGENASE has 1 sense:

1. either of two related enzymes that control the production of prostaglandins and are blocked by aspirin

  Familiarity information: CYCLOOXYGENASE used as a noun is very rare.

 Dictionary entry details 

• CYCLOOXYGENASE (noun)

Sense 1

Meaning:

Either of two related enzymes that control the production of prostaglandins and are blocked by aspirin

Classified under:

Nouns denoting substances

Synonyms:

Cox; cyclooxygenase

Hypernyms ("cyclooxygenase" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

Hyponyms (each of the following is a kind of "cyclooxygenase"):

Cox-1; cyclooxygenase-1 (an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys)

Cox-2; cyclooxygenase-2 (an enzyme that makes prostaglandins that cause inflammation and pain and fever)

 Context examples 

Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors.

(Diflunisal, NCI Thesaurus)

In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase.

(Ebselen, NCI Thesaurus)

Diclofenac binds to and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid (AA) to pro-inflammatory prostaglandins.

(Diclofenac sodium gel, NCI Thesaurus)

It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.

(Diclofenac, NCI Dictionary)

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.

(Cyclooxygenase inhibitor, NLM, Medical Subject Headings)

Some tumors have high levels of cyclooxygenase-2 and blocking its activity may reduce tumor growth.

(Cyclooxygenase-2, NCI Dictionary)

Mesalamine may reduce inflammation through inhibition of cyclooxygenase and prostaglandin production.

(Mesalamine, NCI Thesaurus)

This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2.

(Nafazatrom, NCI Thesaurus)

As a first generation NSAID inhibitor, oxaprozin binds to and inactivates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins.

(Oxaprozin, NCI Thesaurus)

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain.

(Piroxicam, NLM, Medical Subject Headings)