CROSS-LINKAGE

Pronunciation (US):

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 Dictionary entry overview: What does cross-linkage mean? 

• CROSS-LINKAGE (noun)
  The noun CROSS-LINKAGE has 1 sense:

1. a side bond that links two adjacent chains of atoms in a complex molecule

  Familiarity information: CROSS-LINKAGE used as a noun is very rare.

 Dictionary entry details 

• CROSS-LINKAGE (noun)

Sense 1

Meaning:

A side bond that links two adjacent chains of atoms in a complex molecule

Classified under:

Nouns denoting natural phenomena

Synonyms:

cross-link; cross-linkage

Hypernyms ("cross-linkage" is a kind of...):

bond; chemical bond (an electrical force linking atoms)

Derivation:

cross-link (join by creating covalent bonds (of adjacent chains of a polymer or protein))

 Context examples 

It also inhibits the cross-linkage of peptidoglycan, a critical component of bacterial cell walls.

(Dicloxacillin, NCI Thesaurus)

Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall.

(Cloxacillin, NCI Thesaurus)

After intratumoral injection, cisplatin alkylates guanine nucleosides in DNA, and causes DNA-DNA or DNA-protein cross-linkages, thereby preventing DNA replication and resulting in tumor cell growth inhibition and apoptosis.

(Cisplatin-E Therapeutic Implant, NCI Thesaurus)

Galectin 8 may be involved in activation of various cell types through cross-linkage of cell surface glycoproteins and may be involved in some types of cancer.

(Galectin 8, NCI Thesaurus)

Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.

(Melphalan, NCI Thesaurus)

Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis.

(Picoplatin, NCI Thesaurus)

Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and RNA transcription and the induction of apoptosis.

(Oral Picoplatin, NCI Thesaurus)

Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages.

(Melphalan-Flufenamide Prodrug, NCI Thesaurus)

Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis.

(Cefazolin Sodium, NCI Thesaurus)

Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis.

(Cefepime Hydrochloride, NCI Thesaurus)