CROSS-LINK

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does cross-link mean? 

• CROSS-LINK (noun)
  The noun CROSS-LINK has 1 sense:

1. a side bond that links two adjacent chains of atoms in a complex molecule

  Familiarity information: CROSS-LINK used as a noun is very rare.

• CROSS-LINK (verb)
  The verb CROSS-LINK has 1 sense:

1. join by creating covalent bonds (of adjacent chains of a polymer or protein)

  Familiarity information: CROSS-LINK used as a verb is very rare.

 Dictionary entry details 

• CROSS-LINK (noun)

Sense 1

Meaning:

A side bond that links two adjacent chains of atoms in a complex molecule

Classified under:

Nouns denoting natural phenomena

Synonyms:

cross-link; cross-linkage

Hypernyms ("cross-link" is a kind of...):

bond; chemical bond (an electrical force linking atoms)

Derivation:

cross-link (join by creating covalent bonds (of adjacent chains of a polymer or protein))

• CROSS-LINK (verb)

Present simple: I / you / we / they cross-link    ... he / she / it cross-links   
Past simple: cross-linked   
Past participle: cross-linked   
-ing form: cross-linking   

Sense 1

Meaning:

Join by creating covalent bonds (of adjacent chains of a polymer or protein)

Classified under:

Verbs of touching, hitting, tying, digging

Hypernyms (to "cross-link" is one way to...):

conjoin; join (make contact or come together)

Sentence frame:

Somebody ----s something

Derivation:

cross-link; cross-linkage (a side bond that links two adjacent chains of atoms in a complex molecule)

 Context examples 

Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains.

(Cefdinir, NCI Thesaurus)

Methicillin sodium is bactericidal and binds to specific penicillin-binding proteins on the bacterium and inhibits the transpeptidation enzyme, thereby preventing the cross-linking of peptidoglycans.

(Methicillin Sodium, NCI Thesaurus)

Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking, thereby inhibiting DNA repair, RNA and protein synthesis.

(Mitindomide, NCI Thesaurus)

Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cell growth.

(Alkylating agent, NCI Thesaurus)

As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.

(Carmustine in Ethanol, NCI Thesaurus)

This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links.

(Carboplatin, NCI Thesaurus)

Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.

(Carmustine, NCI Thesaurus)

Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.

(Mitomycin, NCI Thesaurus)

Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.

(Mitomycin A, NCI Thesaurus)

It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking.

(Oncogene LCK, NCI Thesaurus)