COX

Pronunciation (US):

(GB):

IPA (US):

 Dictionary entry overview: What does Cox mean? 

• COX (noun)
  The noun COX has 2 senses:

1. either of two related enzymes that control the production of prostaglandins and are blocked by aspirin

2. the helmsman of a ship's boat or a racing crew

  Familiarity information: COX used as a noun is rare.

• COX (verb)
  The verb COX has 1 sense:

1. act as the coxswain, in a boat race

  Familiarity information: COX used as a verb is very rare.

 Dictionary entry details 

• COX (noun)

Sense 1

Meaning:

Either of two related enzymes that control the production of prostaglandins and are blocked by aspirin

Classified under:

Nouns denoting substances

Synonyms:

Cox; cyclooxygenase

Hypernyms ("Cox" is a kind of...):

enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)

Hyponyms (each of the following is a kind of "Cox"):

Cox-1; cyclooxygenase-1 (an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys)

Cox-2; cyclooxygenase-2 (an enzyme that makes prostaglandins that cause inflammation and pain and fever)

Sense 2

Meaning:

The helmsman of a ship's boat or a racing crew

Classified under:

Nouns denoting people

Synonyms:

cox; coxswain

Hypernyms ("cox" is a kind of...):

helmsman; steerer; steersman (the person who steers a ship)

Derivation:

cox (act as the coxswain, in a boat race)

• COX (verb)

Sense 1

Meaning:

Act as the coxswain, in a boat race

Classified under:

Verbs of political and social activities and events

Hypernyms (to "cox" is one way to...):

be; follow (work in a specific place, with a specific subject, or in a specific function)

Sentence frame:

Somebody ----s

Derivation:

cox (the helmsman of a ship's boat or a racing crew)

 Context examples 

You and Miss Smith, and Miss Fairfax, will be three, and the two Miss Coxes five; and for five couple there will be plenty of room.

(Emma, by Jane Austen)

Arachidonic acid is converted to the prostaglandin PGG2 by the enzyme Cox-1 in platelets, and Cox-1 is inhibited by aspirin, reducing thromboxane A2 production by platelets.

(Aspirin Inhibition of Platelet Activation Pathway, NCI Thesaurus/BIOCARTA)

Until very recently, only two Cox enzymes, Cox-1 and Cox-2, were known to be targets of NSAIDS.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)

PGH2 synthase actually consists of two enzyme components, a cyclooxygenase and a peroxidase, and there are more than one type of cyclooxygenase, including Cox-1 and Cox-2.

(Eicosanoid Metabolism Pathway, NCI Thesaurus/BIOCARTA)

And there will be the two Gilberts, young Cox, my father, and myself, besides Mr. Knightley.

(Emma, by Jane Austen)

NSAIDS selective for Cox-2 have been developed to avoid the development of ulcers by some non-selective NSAIDs, including aspirin.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)

Recent NSAIDS acting selectively as Cox-2 inhibitors like Vioxx are widely used for the treatment of arthritis and other inflammatory conditions, inhibiting the production of downstream thromboxanes and prostaglandins.

(Eicosanoid Metabolism Pathway, NCI Thesaurus/BIOCARTA)

Thromboxane is a potent vasoconstrictor and platelet activator, so inhibition of Cox-1 in platelets by aspirin may explain some of the cardioprotective actions of aspirin.

(Aspirin Inhibition of Platelet Activation Pathway, NCI Thesaurus/BIOCARTA)

“You and Miss Smith, and Miss Fairfax, will be three, and the two Miss Coxes five,” had been repeated many times over.

(Emma, by Jane Austen)

Cox-2 is an inducible enzyme whose expression is induced by inflammation.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)