CORTICAL

Pronunciation (US):

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IPA (US):

 Dictionary entry overview: What does cortical mean? 

• CORTICAL (adjective)
  The adjective CORTICAL has 1 sense:

1. of or relating to a cortex

  Familiarity information: CORTICAL used as an adjective is very rare.

 Dictionary entry details 

• CORTICAL (adjective)

Sense 1

Meaning:

Of or relating to a cortex

Classified under:

Relational adjectives (pertainyms)

Pertainym:

cortex (the tissue forming the outer layer of an organ or structure in plant or animal)

Derivation:

cortex (the layer of unmyelinated neurons (the grey matter) forming the cortex of the cerebrum)

cortex (the tissue forming the outer layer of an organ or structure in plant or animal)

 Context examples 

Metallothionein 3 inhibits survival and neurite formation of cortical neurons in vitro.

(Metallothionein 3, NCI Thesaurus)

Inhibition of cdk5 or calpain activity reduces cell death in A beta-treated cortical neurons.

(Alzheimer's Disease Pathway BioCarta, NCI Thesaurus/BIOCARTA)

A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels.

(Cinacalcet Hydrochloride, NCI Thesaurus)

Dysregulated Notch signaling is implicated in many diseases including T-ALL (T-cell acute lymphoblastic leukemia), CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub-cortical Infarcts and Leukoencephalopathy), MS (Multiple Sclerosis), and many other disease states.

(Anti-Notch Receptor Monoclonal Antibody OMP-59R5, NCI Thesaurus)

This drug stabilizes dopamine and serotonin activity in the limbic and cortical system.

(Aripiprazole, NCI Thesaurus)

A genetic disorder characterized by defects in the synthesis of cortisol and/or aldosterone, resulting in hyperplasia of the adrenal cortical cells.

(Congenital Adrenal Gland Hyperplasia, NCI Thesaurus)

Mutations in this gene are associated with cortical dysplasia-focal epilepsy syndrome and may be involved in autism and the DFNB13 form of nonsyndromic deafness.

(CNTNAP2 wt Allele, NCI Thesaurus)

Encoded by human EMS1 Gene, 550-amino acid Cortactin is an actin-binding protein involved in restructuring of the cortical actin cytoskeleton.

(Cortactin, NCI Thesaurus)

The cortical cell layer of the cerebellum.

(Cortical Cell Layer of the Cerebellum, NCI Thesaurus)

Thus this agent reduces the membrane sodium gradient and prevents cortical seizure signal spreading.

(Mephenytoin, NCI Thesaurus)