CONSTITUTIVE

Pronunciation (US):

(GB):

 Dictionary entry overview: What does constitutive mean? 

• CONSTITUTIVE (adjective)
  The adjective CONSTITUTIVE has 1 sense:

1. constitutional in the structure of something (especially your physical makeup)

  Familiarity information: CONSTITUTIVE used as an adjective is very rare.

 Dictionary entry details 

• CONSTITUTIVE (adjective)

Sense 1

Meaning:

Constitutional in the structure of something (especially your physical makeup)

Synonyms:

constituent; constitutional; constitutive; organic

Similar:

essential (basic and fundamental)

 Context examples 

Cox-1 is expressed in a constitutive manner throughout most tissues, and plays an essential role in maintaining the integrity of the stomach mucosal lining.

(Acetaminophen Pathway, NCI Thesaurus/BIOCARTA)

This protein is involved in constitutive signaling and tyrosine phosphorylation.

(High Affinity Nerve Growth Factor Receptor Isoform TrkA-III, NCI Thesaurus)

Constitutive activation of Hh pathway signaling has been observed in various types of malignancies.

(Hedgehog Inhibitor PF-04449913, NCI Thesaurus)

High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy.

(HMGA Family Protein, NCI Thesaurus)

Host Defenses against pathology include physical barriers to pathogens, immediate nonspecific and constitutive (innate) defenses, specific inducible immune responses, metabolic and physiologic homeostatic mechanisms, detoxification, repair processes, and healing mechanisms.

(Host Defense, NCI Thesaurus)

Some oncogenic RET point mutations cause constitutive kinase activation.

(Oncogene RET, NCI Thesaurus)

Constitutive activation of Mek1 can transform cells and may play a role in cancer.

(MAP Kinase Downregulation Pathway, NCI Thesaurus/BIOCARTA)

Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation.

(ISIS 5132, NCI Thesaurus)

A genetic abnormality that arises from duplications of the juxtamembrane portion of the gene and results in constitutive activation of the FLT3 receptor tyrosine kinase protein in early hematopoietic progenitor cells.

(FLT3 Internal Tandem Duplication, NCI Thesaurus)

This soluble, nuclear protein plays a role in establishment of constitutive heterochromatin at pericentric and telomeric regions.

(Histone-Lysine N-Methyltransferase SUV39H1, NCI Thesaurus)